| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK3 | XPO5 | Ser416 | GFPSKTDsPSCEYSR | phosphorylation down-regulates activity | 27846390 | SIGNOR-262979 |
| MAPK1 | XPO5 | Ser416 | GFPSKTDsPSCEYSR | phosphorylation down-regulates activity | 27846390 | SIGNOR-262978 |
| ERK1/2 | XPO5 | Ser416 | GFPSKTDsPSCEYSR | phosphorylation down-regulates activity | 27846390 | SIGNOR-262980 |
| ERK1/2 | XPO5 | Ser497 | GSLCSVFsPSFVQWE | phosphorylation down-regulates activity | 27846390 | SIGNOR-262983 |
| Gbeta | XPO5 | – | phosphorylation down-regulates activity | 27846390 | SIGNOR-269999 | |
| MAPK3 | XPO5 | Ser497 | GSLCSVFsPSFVQWE | phosphorylation down-regulates activity | 27846390 | SIGNOR-262982 |
| MAPK1 | XPO5 | Ser497 | GSLCSVFsPSFVQWE | phosphorylation down-regulates activity | 27846390 | SIGNOR-262981 |
| ERK1/2 | XPO5 | Thr345 | GADSDVEtPSNFGKY | phosphorylation down-regulates activity | 27846390 | SIGNOR-262986 |
| MAPK3 | XPO5 | Thr345 | GADSDVEtPSNFGKY | phosphorylation down-regulates activity | 27846390 | SIGNOR-262985 |
| MAPK1 | XPO5 | Thr345 | GADSDVEtPSNFGKY | phosphorylation down-regulates activity | 27846390 | SIGNOR-262984 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK3 | phosphorylation up-regulates → | XPO5 PSer416 | phosphorylation down-regulates ⊣ | XPO5 | 27846390 | SIGNOR-262979 |
| MAPK1 | phosphorylation up-regulates → | XPO5 PSer416 | phosphorylation down-regulates ⊣ | XPO5 | 27846390 | SIGNOR-262978 |
| ERK1/2 | phosphorylation up-regulates → | XPO5 PSer416 | phosphorylation down-regulates ⊣ | XPO5 | 27846390 | SIGNOR-262980 |
| ERK1/2 | phosphorylation up-regulates → | XPO5 PSer497 | phosphorylation down-regulates ⊣ | XPO5 | 27846390 | SIGNOR-262983 |
| MAPK3 | phosphorylation up-regulates → | XPO5 PSer497 | phosphorylation down-regulates ⊣ | XPO5 | 27846390 | SIGNOR-262982 |
| MAPK1 | phosphorylation up-regulates → | XPO5 PSer497 | phosphorylation down-regulates ⊣ | XPO5 | 27846390 | SIGNOR-262981 |
| ERK1/2 | phosphorylation up-regulates → | XPO5 PThr345 | phosphorylation down-regulates ⊣ | XPO5 | 27846390 | SIGNOR-262986 |
| MAPK3 | phosphorylation up-regulates → | XPO5 PThr345 | phosphorylation down-regulates ⊣ | XPO5 | 27846390 | SIGNOR-262985 |
| MAPK1 | phosphorylation up-regulates → | XPO5 PThr345 | phosphorylation down-regulates ⊣ | XPO5 | 27846390 | SIGNOR-262984 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK3 | phosphorylation → down-regulates activity | XPO5 | SIGNOR-262979 |
| MAPK1 | phosphorylation → down-regulates activity | XPO5 | SIGNOR-262978 |
| ERK1/2 | phosphorylation → down-regulates activity | XPO5 | SIGNOR-262980 |
| ERK1/2 | phosphorylation → down-regulates activity | XPO5 | SIGNOR-262983 |
| Gbeta | phosphorylation → down-regulates activity | XPO5 | SIGNOR-269999 |
| MAPK3 | phosphorylation → down-regulates activity | XPO5 | SIGNOR-262982 |
| MAPK1 | phosphorylation → down-regulates activity | XPO5 | SIGNOR-262981 |
| ERK1/2 | phosphorylation → down-regulates activity | XPO5 | SIGNOR-262986 |
| MAPK3 | phosphorylation → down-regulates activity | XPO5 | SIGNOR-262985 |
| MAPK1 | phosphorylation → down-regulates activity | XPO5 | SIGNOR-262984 |
