| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDC7 | CLSPN | – | phosphorylation up-regulates activity | 27401717 | SIGNOR-279360 | |
| PI4K2A | CLSPN | Ser984 | ALALCSGsFPTDKEE | phosphorylation down-regulates | 18082599 | SIGNOR-159937 |
| CHEK1 | CLSPN | Thr916 | DELLDLCtGKFTSQA | phosphorylation up-regulates | 16963448 | SIGNOR-149411 |
| PLK1 | CLSPN | Ser30 | EADSPSDsGQGSYET | phosphorylation down-regulates | 16885022 | SIGNOR-148447 |
| PLK1 | CLSPN | Ser30 | EADSPSDsGQGSYET | phosphorylation down-regulates | 16885021 | SIGNOR-148442 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PI4K2A | phosphorylation up-regulates → | CLSPN PSer984 | phosphorylation down-regulates ⊣ | CLSPN | 18082599 | SIGNOR-159937 |
| CHEK1 | phosphorylation up-regulates → | CLSPN PThr916 | phosphorylation up-regulates → | CLSPN | 16963448 | SIGNOR-149411 |
| PLK1 | phosphorylation up-regulates → | CLSPN PSer30 | phosphorylation down-regulates ⊣ | CLSPN | 16885022 | SIGNOR-148447 |
| PLK1 | phosphorylation up-regulates → | CLSPN PSer30 | phosphorylation down-regulates ⊣ | CLSPN | 16885021 | SIGNOR-148442 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CDC7 | phosphorylation → up-regulates activity | CLSPN | SIGNOR-279360 |
| PI4K2A | phosphorylation down-regulates | CLSPN | SIGNOR-159937 |
| CHEK1 | phosphorylation → up-regulates | CLSPN | SIGNOR-149411 |
| PLK1 | phosphorylation down-regulates | CLSPN | SIGNOR-148447 |
| PLK1 | phosphorylation down-regulates | CLSPN | SIGNOR-148442 |
