| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CHEK1 | FANCE | Thr346 | LGLLRLCtWLLALSP | phosphorylation up-regulates | 17296736 | SIGNOR-153027 |
| CHEK1 | FANCE | Ser374 | LFLGRILsLTSSASR | phosphorylation up-regulates | 17296736 | SIGNOR-153023 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CHEK1 | phosphorylation up-regulates → | FANCE PThr346 | phosphorylation up-regulates → | FANCE | 17296736 | SIGNOR-153027 |
| CHEK1 | phosphorylation up-regulates → | FANCE PSer374 | phosphorylation up-regulates → | FANCE | 17296736 | SIGNOR-153023 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CHEK1 | phosphorylation → up-regulates | FANCE | SIGNOR-153027 |
| CHEK1 | phosphorylation → up-regulates | FANCE | SIGNOR-153023 |
