| Name | MKNK2 |
| ID | Q9HBH9 |
| Role | substrate |
| Enzymatic Domains |
Protein kinase 84-388 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MTOR | MKNK2 | Ser74 | KRGRATDsFSGRFED | phosphorylation down-regulates activity | 32170339 | SIGNOR-277516 |
| MAPK1 | MKNK2 | – | phosphorylation up-regulates | 9155017 | SIGNOR-48338 | |
| ERK1/2 | MKNK2 | – | phosphorylation up-regulates | 9155017 | SIGNOR-270204 | |
| MAPK14 | MKNK2 | – | phosphorylation up-regulates | 9155017 | SIGNOR-48349 | |
| MAPK3 | MKNK2 | – | phosphorylation up-regulates | 9155017 | SIGNOR-48355 | |
| Gbeta | MKNK2 | – | phosphorylation up-regulates | 9155017 | SIGNOR-270115 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MTOR | phosphorylation up-regulates → | MKNK2 PSer74 | phosphorylation down-regulates ⊣ | MKNK2 | 32170339 | SIGNOR-277516 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MTOR | phosphorylation → down-regulates activity | MKNK2 | SIGNOR-277516 |
| MAPK1 | phosphorylation → up-regulates | MKNK2 | SIGNOR-48338 |
| ERK1/2 | phosphorylation → up-regulates | MKNK2 | SIGNOR-270204 |
| MAPK14 | phosphorylation → up-regulates | MKNK2 | SIGNOR-48349 |
| MAPK3 | phosphorylation → up-regulates | MKNK2 | SIGNOR-48355 |
| Gbeta | phosphorylation → up-regulates | MKNK2 | SIGNOR-270115 |