Entity Details

Name SGK2
ID Q9HBY8
Role kinase
Enzymatic Domains
Protein kinase 35-292
PROSITE-ProRule
AGC-kinase C-terminal 293-367
PROSITE-ProRule
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
SGK2FOXO3Ser253APRRRAVsMDNSNKYphosphorylation
down-regulates activity		11154281SIGNOR-249130
SGK2FOXO3Thr32QSRPRSCtWPLQRPEphosphorylation
down-regulates activity		11154281SIGNOR-249132
SGK2FOXOSer253APRRRAVsMDNSNKYphosphorylation
down-regulates activity		11154281SIGNOR-252990
SGK2FOXOThr32QSRPRSCtWPLQRPEphosphorylation
down-regulates activity		11154281SIGNOR-252991
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
SGK2phosphorylation
up-regulates
→
FOXO3
PSer253		phosphorylation
down-regulates
⊣		FOXO311154281SIGNOR-249130
SGK2phosphorylation
up-regulates
→
FOXO3
PThr32		phosphorylation
down-regulates
⊣		FOXO311154281SIGNOR-249132
SGK2phosphorylation
up-regulates
→
FOXO
PSer253		phosphorylation
down-regulates
⊣		FOXO11154281SIGNOR-252990
SGK2phosphorylation
up-regulates
→
FOXO
PThr32		phosphorylation
down-regulates
⊣		FOXO11154281SIGNOR-252991
Regulator Mechanism/Effect Target SIGNOR-ID
SGK2phosphorylation
→
down-regulates activity 		FOXO3SIGNOR-249130
SGK2phosphorylation
→
down-regulates activity 		FOXO3SIGNOR-249132
SGK2phosphorylation
→
down-regulates activity 		FOXOSIGNOR-252990
SGK2phosphorylation
→
down-regulates activity 		FOXOSIGNOR-252991