Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
NEK6	SGK1	Ser377	PPFNPNVsGPNDLRH	phosphorylation up-regulates activity	12023960	SIGNOR-262954
NEK6	SGK1	Ser377	PPFNPNVsGPNDLRH	phosphorylation up-regulates activity	12023960	SIGNOR-250296
NEK6	SGK1	Ser422	AEAFLGFsYAPPTDS	phosphorylation up-regulates activity	12023960	SIGNOR-250297
NEK6	KIF20A	Ser244	LSTSLKRsVYIESRI	phosphorylation down-regulates activity	28630147	SIGNOR-273891
NEK6	HSPA1A	Thr66	VALNPQNtVFDAKRL	phosphorylation up-regulates activity	30108182	SIGNOR-273885
NEK6	RPS6KB1	Ser403	DDSTLSEsANQVFLG	phosphorylation up-regulates activity	12023960	SIGNOR-262953
NEK6	RPS6KB1	Ser53	EGGQLNEsMDHGGVG	phosphorylation up-regulates activity	12023960	SIGNOR-262952
NEK6	BSG	Ser368	GSAPLKSsGQHQNDK	phosphorylation down-regulates activity	31016558	SIGNOR-273882
NEK6	STAT3	Ser727	NTIDLPMsPRTLDSL	phosphorylation up-regulates activity	20595392	SIGNOR-273902
NEK6	STAT3	Tyr705	DPGSAAPyLKTKFIC	phosphorylation up-regulates activity	20595392	SIGNOR-273901
NEK6	KIF11	Ser1033	GINTLERsKVEETTE	phosphorylation up-regulates activity	19001501	SIGNOR-273886
NEK6	NUP98	Ser608	VLKNLNNsNLFSPVN	phosphorylation down-regulates activity	21335236	SIGNOR-273892
NEK6	NUP98	Ser839	TSRCLIKsPDRLADI	phosphorylation down-regulates activity	21335236	SIGNOR-273893
NEK6	PSMD2	Ser361	ENNRFGGsGSQVDSA	phosphorylation up-regulates activity	31843888	SIGNOR-273894
NEK6	ACD	Ser169	SNAGLSLsQLLDEMR	phosphorylation up-regulates activity	27396482	SIGNOR-264424
NEK6	EML4	Ser146	PQIRASPsPQPSSQP	phosphorylation down-regulates activity	31409757	SIGNOR-279236
NEK6	EML4	Ser144	QSPQIRAsPSPQPSS	phosphorylation up-regulates activity	31409757	SIGNOR-273883
NEK6	FOXJ2	Ser254	NFQDLSWsFRNLYKS	phosphorylation up-regulates activity	27899381	SIGNOR-278965
NEK6	FOXJ2	Thr23	PQLTLRAtIEKLGSA	phosphorylation up-regulates activity	27899381	SIGNOR-278964

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
NEK6	phosphorylation up-regulates →	SGK1 PSer377	phosphorylation up-regulates →	SGK1	12023960	SIGNOR-262954
NEK6	phosphorylation up-regulates →	SGK1 PSer377	phosphorylation up-regulates →	SGK1	12023960	SIGNOR-250296
NEK6	phosphorylation up-regulates →	SGK1 PSer422	phosphorylation up-regulates →	SGK1	12023960	SIGNOR-250297
NEK6	phosphorylation up-regulates →	KIF20A PSer244	phosphorylation down-regulates ⊣	KIF20A	28630147	SIGNOR-273891
NEK6	phosphorylation up-regulates →	HSPA1A PThr66	phosphorylation up-regulates →	HSPA1A	30108182	SIGNOR-273885
NEK6	phosphorylation up-regulates →	RPS6KB1 PSer403	phosphorylation up-regulates →	RPS6KB1	12023960	SIGNOR-262953
NEK6	phosphorylation up-regulates →	RPS6KB1 PSer53	phosphorylation up-regulates →	RPS6KB1	12023960	SIGNOR-262952
NEK6	phosphorylation up-regulates →	BSG PSer368	phosphorylation down-regulates ⊣	BSG	31016558	SIGNOR-273882
NEK6	phosphorylation up-regulates →	STAT3 PSer727	phosphorylation up-regulates →	STAT3	20595392	SIGNOR-273902
NEK6	phosphorylation up-regulates →	STAT3 PTyr705	phosphorylation up-regulates →	STAT3	20595392	SIGNOR-273901
NEK6	phosphorylation up-regulates →	KIF11 PSer1033	phosphorylation up-regulates →	KIF11	19001501	SIGNOR-273886
NEK6	phosphorylation up-regulates →	NUP98 PSer608	phosphorylation down-regulates ⊣	NUP98	21335236	SIGNOR-273892
NEK6	phosphorylation up-regulates →	NUP98 PSer839	phosphorylation down-regulates ⊣	NUP98	21335236	SIGNOR-273893
NEK6	phosphorylation up-regulates →	PSMD2 PSer361	phosphorylation up-regulates →	PSMD2	31843888	SIGNOR-273894
NEK6	phosphorylation up-regulates →	ACD PSer169	phosphorylation up-regulates →	ACD	27396482	SIGNOR-264424
NEK6	phosphorylation up-regulates →	EML4 PSer146	phosphorylation down-regulates ⊣	EML4	31409757	SIGNOR-279236
NEK6	phosphorylation up-regulates →	EML4 PSer144	phosphorylation up-regulates →	EML4	31409757	SIGNOR-273883
NEK6	phosphorylation up-regulates →	FOXJ2 PSer254	phosphorylation up-regulates →	FOXJ2	27899381	SIGNOR-278965
NEK6	phosphorylation up-regulates →	FOXJ2 PThr23	phosphorylation up-regulates →	FOXJ2	27899381	SIGNOR-278964

Regulator	Mechanism/Effect	Target	SIGNOR-ID
NEK6	phosphorylation → up-regulates activity	SGK1	SIGNOR-262954
NEK6	phosphorylation → up-regulates activity	SGK1	SIGNOR-250296
NEK6	phosphorylation → up-regulates activity	SGK1	SIGNOR-250297
NEK6	phosphorylation → down-regulates activity	KIF20A	SIGNOR-273891
NEK6	phosphorylation → up-regulates activity	HSPA1A	SIGNOR-273885
NEK6	phosphorylation → up-regulates activity	RPS6KB1	SIGNOR-262953
NEK6	phosphorylation → up-regulates activity	RPS6KB1	SIGNOR-262952
NEK6	phosphorylation → down-regulates activity	BSG	SIGNOR-273882
NEK6	phosphorylation → up-regulates activity	STAT3	SIGNOR-273902
NEK6	phosphorylation → up-regulates activity	STAT3	SIGNOR-273901
NEK6	phosphorylation → up-regulates activity	KIF11	SIGNOR-273886
NEK6	phosphorylation → down-regulates activity	NUP98	SIGNOR-273892
NEK6	phosphorylation → down-regulates activity	NUP98	SIGNOR-273893
NEK6	phosphorylation → up-regulates activity	PSMD2	SIGNOR-273894
NEK6	phosphorylation → up-regulates activity	ACD	SIGNOR-264424
NEK6	phosphorylation → down-regulates activity	EML4	SIGNOR-279236
NEK6	phosphorylation → up-regulates activity	EML4	SIGNOR-273883
NEK6	phosphorylation → up-regulates activity	FOXJ2	SIGNOR-278965
NEK6	phosphorylation → up-regulates activity	FOXJ2	SIGNOR-278964