| Name | PTPRH |
| ID | Q9HD43 |
| Role | phosphatase |
| Enzymatic Domains |
Fibronectin type-III 1 32-121 PROSITE-ProRule
Fibronectin type-III 2 122-209 PROSITE-ProRule
Fibronectin type-III 3 210-299 PROSITE-ProRule
Fibronectin type-III 4 300-387 PROSITE-ProRule
Fibronectin type-III 5 388-477 PROSITE-ProRule
Fibronectin type-III 6 478-563 PROSITE-ProRule
Fibronectin type-III 7 564-666 PROSITE-ProRule
Fibronectin type-III 8 665-749 PROSITE-ProRule
Tyrosine-protein phosphatase 820-1079 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPRH | EGFR | – | dephosphorylation down-regulates activity | 28065597 | SIGNOR-277090 | |
| PTPRH | INSR | Tyr1185 | FGMTRDIyETDYYRK | dephosphorylation down-regulates | 10734133 | SIGNOR-76072 |
| PTPRH | INSR | Tyr1189 | RDIYETDyYRKGGKG | dephosphorylation down-regulates | 10734133 | SIGNOR-76076 |
| PTPRH | INSR | Tyr1190 | DIYETDYyRKGGKGL | dephosphorylation down-regulates | 10734133 | SIGNOR-76080 |
| PTPRH | INSR | Tyr999 | YASSNPEyLSASDVF | dephosphorylation down-regulates | 10734133 | SIGNOR-76084 |
| PTPRH | GHR | – | dephosphorylation down-regulates activity | 12907755 | SIGNOR-248802 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPRH | dephosphorylation down-regulates ⊣ | INSR PTyr1185 | dephosphorylation up-regulates → | INSR | 10734133 | SIGNOR-76072 |
| PTPRH | dephosphorylation down-regulates ⊣ | INSR PTyr1189 | dephosphorylation up-regulates → | INSR | 10734133 | SIGNOR-76076 |
| PTPRH | dephosphorylation down-regulates ⊣ | INSR PTyr1190 | dephosphorylation up-regulates → | INSR | 10734133 | SIGNOR-76080 |
| PTPRH | dephosphorylation down-regulates ⊣ | INSR PTyr999 | dephosphorylation up-regulates → | INSR | 10734133 | SIGNOR-76084 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTPRH | dephosphorylation → down-regulates activity | EGFR | SIGNOR-277090 |
| PTPRH | dephosphorylation down-regulates | INSR | SIGNOR-76072 |
| PTPRH | dephosphorylation down-regulates | INSR | SIGNOR-76076 |
| PTPRH | dephosphorylation down-regulates | INSR | SIGNOR-76080 |
| PTPRH | dephosphorylation down-regulates | INSR | SIGNOR-76084 |
| PTPRH | dephosphorylation → down-regulates activity | GHR | SIGNOR-248802 |