| Name | PLCB1 |
| ID | Q9NQ66 |
| Role | substrate |
| Enzymatic Domains |
PI-PLC X-box 316-467 PROSITE-ProRule
PI-PLC Y-box 540-656 PROSITE-ProRule
C2 656-786 PROSITE-ProRule |
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|
| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK3 | PLCB1 | Ser982 | KKKSEPSsPDHGSST | phosphorylation up-regulates activity | 11287604 | SIGNOR-106565 |
| PRKCA | PLCB1 | Ser887 | HSQPAPGsVKAPAKT | phosphorylation unknown | 11278470 | SIGNOR-249081 |
| ERK1/2 | PLCB1 | – | phosphorylation up-regulates activity | 11287604 | SIGNOR-270200 | |
| Gbeta | PLCB1 | – | phosphorylation up-regulates activity | 11287604 | SIGNOR-270109 | |
| MAPK1 | PLCB1 | Ser982 | KKKSEPSsPDHGSST | phosphorylation up-regulates activity | 11287604 | SIGNOR-106561 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK3 | phosphorylation up-regulates → | PLCB1 PSer982 | phosphorylation up-regulates → | PLCB1 | 11287604 | SIGNOR-106565 |
| PRKCA | phosphorylation up-regulates → | PLCB1 PSer887 | phosphorylation down-regulates ⊣ | PLCB1 | 11278470 | SIGNOR-249081 |
| MAPK1 | phosphorylation up-regulates → | PLCB1 PSer982 | phosphorylation up-regulates → | PLCB1 | 11287604 | SIGNOR-106561 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK3 | phosphorylation → up-regulates activity | PLCB1 | SIGNOR-106565 |
| PRKCA | phosphorylation → unknown | PLCB1 | SIGNOR-249081 |
| ERK1/2 | phosphorylation → up-regulates activity | PLCB1 | SIGNOR-270200 |
| Gbeta | phosphorylation → up-regulates activity | PLCB1 | SIGNOR-270109 |
| MAPK1 | phosphorylation → up-regulates activity | PLCB1 | SIGNOR-106561 |