| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CSNK2A1 | TCF7L2 | Ser59 | SETNQNSsSDSEAER | phosphorylation up-regulates activity | 11711551 | SIGNOR-250963 |
| CSNK2A1 | TCF7L2 | Ser58 | ESETNQNsSSDSEAE | phosphorylation up-regulates activity | 11711551 | SIGNOR-250962 |
| NLK | TCF7L2 | Thr212 | TYSNEHFtPGNPPPH | phosphorylation down-regulates | 12556497 | SIGNOR-97873 |
| NLK | TCF7L2 | – | phosphorylation down-regulates quantity | 16714285 | SIGNOR-271597 | |
| CSNK2A2 | TCF7L2 | Ser60 | ETNQNSSsDSEAERR | phosphorylation up-regulates activity | 11711551 | SIGNOR-251046 |
| NLK | TCF7L2 | Thr201 | PHHVHPLtPLITYSN | phosphorylation down-regulates | 12556497 | SIGNOR-97819 |
| TNIK | TCF7L2 | Ser177 | QALKDARsPSPAHIV | phosphorylation up-regulates | 20530691 | SIGNOR-165946 |
| CSNK2A2 | TCF7L2 | Ser58 | ESETNQNsSSDSEAE | phosphorylation up-regulates activity | 11711551 | SIGNOR-251044 |
| CSNK2A1 | TCF7L2 | Ser60 | ETNQNSSsDSEAERR | phosphorylation up-regulates activity | 11711551 | SIGNOR-250964 |
| CSNK2A2 | TCF7L2 | Ser59 | SETNQNSsSDSEAER | phosphorylation up-regulates activity | 11711551 | SIGNOR-251045 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CSNK2A1 | phosphorylation up-regulates → | TCF7L2 PSer59 | phosphorylation up-regulates → | TCF7L2 | 11711551 | SIGNOR-250963 |
| CSNK2A1 | phosphorylation up-regulates → | TCF7L2 PSer58 | phosphorylation up-regulates → | TCF7L2 | 11711551 | SIGNOR-250962 |
| NLK | phosphorylation up-regulates → | TCF7L2 PThr212 | phosphorylation down-regulates ⊣ | TCF7L2 | 12556497 | SIGNOR-97873 |
| CSNK2A2 | phosphorylation up-regulates → | TCF7L2 PSer60 | phosphorylation up-regulates → | TCF7L2 | 11711551 | SIGNOR-251046 |
| NLK | phosphorylation up-regulates → | TCF7L2 PThr201 | phosphorylation down-regulates ⊣ | TCF7L2 | 12556497 | SIGNOR-97819 |
| TNIK | phosphorylation up-regulates → | TCF7L2 PSer177 | phosphorylation up-regulates → | TCF7L2 | 20530691 | SIGNOR-165946 |
| CSNK2A2 | phosphorylation up-regulates → | TCF7L2 PSer58 | phosphorylation up-regulates → | TCF7L2 | 11711551 | SIGNOR-251044 |
| CSNK2A1 | phosphorylation up-regulates → | TCF7L2 PSer60 | phosphorylation up-regulates → | TCF7L2 | 11711551 | SIGNOR-250964 |
| CSNK2A2 | phosphorylation up-regulates → | TCF7L2 PSer59 | phosphorylation up-regulates → | TCF7L2 | 11711551 | SIGNOR-251045 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CSNK2A1 | phosphorylation → up-regulates activity | TCF7L2 | SIGNOR-250963 |
| CSNK2A1 | phosphorylation → up-regulates activity | TCF7L2 | SIGNOR-250962 |
| NLK | phosphorylation down-regulates | TCF7L2 | SIGNOR-97873 |
| NLK | phosphorylation → down-regulates quantity | TCF7L2 | SIGNOR-271597 |
| CSNK2A2 | phosphorylation → up-regulates activity | TCF7L2 | SIGNOR-251046 |
| NLK | phosphorylation down-regulates | TCF7L2 | SIGNOR-97819 |
| TNIK | phosphorylation → up-regulates | TCF7L2 | SIGNOR-165946 |
| CSNK2A2 | phosphorylation → up-regulates activity | TCF7L2 | SIGNOR-251044 |
| CSNK2A1 | phosphorylation → up-regulates activity | TCF7L2 | SIGNOR-250964 |
| CSNK2A2 | phosphorylation → up-regulates activity | TCF7L2 | SIGNOR-251045 |
