| Name | CYLD |
| ID | Q9NQC7 |
| Role | substrate |
| Enzymatic Domains |
CAP-Gly 1 153-198 PROSITE-ProRule
CAP-Gly 2 253-286 PROSITE-ProRule
CAP-Gly 3 492-535 PROSITE-ProRule
USP 592-950 |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| IKBKB | CYLD | Ser444 | PLSLSAQsVMEELNT | phosphorylation down-regulates activity | 24614225 | SIGNOR-204740 |
| IKBKB | CYLD | Ser436 | TNGSIGHsPLSLSAQ | phosphorylation down-regulates activity | 24614225 | SIGNOR-204728 |
| IKBKB | CYLD | Ser441 | GHSPLSLsAQSVMEE | phosphorylation up-regulates activity | 24614225 | SIGNOR-204736 |
| CAMK2A | CYLD | Ser772 | LFKKIFPsLELNITD | phosphorylation up-regulates activity | 24614225 | SIGNOR-266441 |
| CAMK2A | CYLD | Ser362 | FYTLNGSsVDSQPQS | phosphorylation up-regulates activity | 24614225 | SIGNOR-266434 |
| CHUK | CYLD | Ser422 | RFHSLPFsLTKMPNT | phosphorylation up-regulates activity | 24614225 | SIGNOR-204692 |
| CAMK2A | CYLD | Ser772 | LFKKIFPsLELNITD | phosphorylation up-regulates activity | 24614225 | SIGNOR-266433 |
| CHUK | CYLD | Ser436 | TNGSIGHsPLSLSAQ | phosphorylation down-regulates activity | 24614225 | SIGNOR-204700 |
| CHUK | CYLD | Ser439 | SIGHSPLsLSAQSVM | phosphorylation down-regulates activity | 24614225 | SIGNOR-204704 |
| IKBKB | CYLD | Ser418 | TTENRFHsLPFSLTK | phosphorylation down-regulates activity | 24614225 | SIGNOR-204716 |
| CHUK | CYLD | Ser444 | PLSLSAQsVMEELNT | phosphorylation down-regulates activity | 24614225 | SIGNOR-204712 |
| CHUK | CYLD | Ser432 | KMPNTNGsIGHSPLS | phosphorylation down-regulates activity | 24614225 | SIGNOR-204696 |
| IKK-complex | CYLD | Ser418 | TTENRFHsLPFSLTK | phosphorylation down-regulates activity | 15870263 | SIGNOR-266435 |
| IKBKB | CYLD | Ser418 | TTENRFHsLPFSLTK | phosphorylation down-regulates activity | 15870263 | SIGNOR-266436 |
| CHUK | CYLD | Ser441 | GHSPLSLsAQSVMEE | phosphorylation up-regulates activity | 24614225 | SIGNOR-204708 |
| CAMK2A | CYLD | Ser362 | FYTLNGSsVDSQPQS | phosphorylation up-regulates activity | 24614225 | SIGNOR-266442 |
| IKBKB | CYLD | Ser439 | SIGHSPLsLSAQSVM | phosphorylation down-regulates activity | 24614225 | SIGNOR-204732 |
| CHUK | CYLD | Ser418 | TTENRFHsLPFSLTK | phosphorylation down-regulates activity | 24614225 | SIGNOR-204688 |
| CAMK2B | CYLD | Ser362 | FYTLNGSsVDSQPQS | phosphorylation up-regulates | 24614225 | SIGNOR-25334 |
| CAMK2B | CYLD | Ser418 | TTENRFHsLPFSLTK | phosphorylation up-regulates activity | 24614225 | SIGNOR-25329 |
| CAMK2B | CYLD | Ser772 | LFKKIFPsLELNITD | phosphorylation up-regulates | 24614225 | SIGNOR-91403 |
| IKBKB | CYLD | Ser432 | KMPNTNGsIGHSPLS | phosphorylation down-regulates activity | 24614225 | SIGNOR-204724 |
| IKBKB | CYLD | Ser422 | RFHSLPFsLTKMPNT | phosphorylation up-regulates activity | 24614225 | SIGNOR-204720 |
| IKBKE | CYLD | Ser418 | TTENRFHsLPFSLTK | phosphorylation down-regulates activity | 19481526 | SIGNOR-278311 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| IKBKB | phosphorylation up-regulates → | CYLD PSer444 | phosphorylation down-regulates ⊣ | CYLD | 24614225 | SIGNOR-204740 |
| IKBKB | phosphorylation up-regulates → | CYLD PSer436 | phosphorylation down-regulates ⊣ | CYLD | 24614225 | SIGNOR-204728 |
| IKBKB | phosphorylation up-regulates → | CYLD PSer441 | phosphorylation up-regulates → | CYLD | 24614225 | SIGNOR-204736 |
| CAMK2A | phosphorylation up-regulates → | CYLD PSer772 | phosphorylation up-regulates → | CYLD | 24614225 | SIGNOR-266441 |
| CAMK2A | phosphorylation up-regulates → | CYLD PSer362 | phosphorylation up-regulates → | CYLD | 24614225 | SIGNOR-266434 |
| CHUK | phosphorylation up-regulates → | CYLD PSer422 | phosphorylation up-regulates → | CYLD | 24614225 | SIGNOR-204692 |
| CAMK2A | phosphorylation up-regulates → | CYLD PSer772 | phosphorylation up-regulates → | CYLD | 24614225 | SIGNOR-266433 |
| CHUK | phosphorylation up-regulates → | CYLD PSer436 | phosphorylation down-regulates ⊣ | CYLD | 24614225 | SIGNOR-204700 |
| CHUK | phosphorylation up-regulates → | CYLD PSer439 | phosphorylation down-regulates ⊣ | CYLD | 24614225 | SIGNOR-204704 |
| IKBKB | phosphorylation up-regulates → | CYLD PSer418 | phosphorylation down-regulates ⊣ | CYLD | 24614225 | SIGNOR-204716 |
| CHUK | phosphorylation up-regulates → | CYLD PSer444 | phosphorylation down-regulates ⊣ | CYLD | 24614225 | SIGNOR-204712 |
| CHUK | phosphorylation up-regulates → | CYLD PSer432 | phosphorylation down-regulates ⊣ | CYLD | 24614225 | SIGNOR-204696 |
| IKK-complex | phosphorylation up-regulates → | CYLD PSer418 | phosphorylation down-regulates ⊣ | CYLD | 15870263 | SIGNOR-266435 |
| IKBKB | phosphorylation up-regulates → | CYLD PSer418 | phosphorylation down-regulates ⊣ | CYLD | 15870263 | SIGNOR-266436 |
| CHUK | phosphorylation up-regulates → | CYLD PSer441 | phosphorylation up-regulates → | CYLD | 24614225 | SIGNOR-204708 |
| CAMK2A | phosphorylation up-regulates → | CYLD PSer362 | phosphorylation up-regulates → | CYLD | 24614225 | SIGNOR-266442 |
| IKBKB | phosphorylation up-regulates → | CYLD PSer439 | phosphorylation down-regulates ⊣ | CYLD | 24614225 | SIGNOR-204732 |
| CHUK | phosphorylation up-regulates → | CYLD PSer418 | phosphorylation down-regulates ⊣ | CYLD | 24614225 | SIGNOR-204688 |
| CAMK2B | phosphorylation up-regulates → | CYLD PSer362 | phosphorylation up-regulates → | CYLD | 24614225 | SIGNOR-25334 |
| CAMK2B | phosphorylation up-regulates → | CYLD PSer418 | phosphorylation up-regulates → | CYLD | 24614225 | SIGNOR-25329 |
| CAMK2B | phosphorylation up-regulates → | CYLD PSer772 | phosphorylation up-regulates → | CYLD | 24614225 | SIGNOR-91403 |
| IKBKB | phosphorylation up-regulates → | CYLD PSer432 | phosphorylation down-regulates ⊣ | CYLD | 24614225 | SIGNOR-204724 |
| IKBKB | phosphorylation up-regulates → | CYLD PSer422 | phosphorylation up-regulates → | CYLD | 24614225 | SIGNOR-204720 |
| IKBKE | phosphorylation up-regulates → | CYLD PSer418 | phosphorylation down-regulates ⊣ | CYLD | 19481526 | SIGNOR-278311 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| IKBKB | phosphorylation → down-regulates activity | CYLD | SIGNOR-204740 |
| IKBKB | phosphorylation → down-regulates activity | CYLD | SIGNOR-204728 |
| IKBKB | phosphorylation → up-regulates activity | CYLD | SIGNOR-204736 |
| CAMK2A | phosphorylation → up-regulates activity | CYLD | SIGNOR-266441 |
| CAMK2A | phosphorylation → up-regulates activity | CYLD | SIGNOR-266434 |
| CHUK | phosphorylation → up-regulates activity | CYLD | SIGNOR-204692 |
| CAMK2A | phosphorylation → up-regulates activity | CYLD | SIGNOR-266433 |
| CHUK | phosphorylation → down-regulates activity | CYLD | SIGNOR-204700 |
| CHUK | phosphorylation → down-regulates activity | CYLD | SIGNOR-204704 |
| IKBKB | phosphorylation → down-regulates activity | CYLD | SIGNOR-204716 |
| CHUK | phosphorylation → down-regulates activity | CYLD | SIGNOR-204712 |
| CHUK | phosphorylation → down-regulates activity | CYLD | SIGNOR-204696 |
| IKK-complex | phosphorylation → down-regulates activity | CYLD | SIGNOR-266435 |
| IKBKB | phosphorylation → down-regulates activity | CYLD | SIGNOR-266436 |
| CHUK | phosphorylation → up-regulates activity | CYLD | SIGNOR-204708 |
| CAMK2A | phosphorylation → up-regulates activity | CYLD | SIGNOR-266442 |
| IKBKB | phosphorylation → down-regulates activity | CYLD | SIGNOR-204732 |
| CHUK | phosphorylation → down-regulates activity | CYLD | SIGNOR-204688 |
| CAMK2B | phosphorylation → up-regulates | CYLD | SIGNOR-25334 |
| CAMK2B | phosphorylation → up-regulates activity | CYLD | SIGNOR-25329 |
| CAMK2B | phosphorylation → up-regulates | CYLD | SIGNOR-91403 |
| IKBKB | phosphorylation → down-regulates activity | CYLD | SIGNOR-204724 |
| IKBKB | phosphorylation → up-regulates activity | CYLD | SIGNOR-204720 |
| IKBKE | phosphorylation → down-regulates activity | CYLD | SIGNOR-278311 |