Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
IKBKE	CYLD	Ser418 View in OncoXplorer	TTENRFHsLPFSLTK	phosphorylation down-regulates activity	19481526	SIGNOR-278311
IKBKB	CYLD	Ser418 View in OncoXplorer	TTENRFHsLPFSLTK	phosphorylation down-regulates activity	15870263	SIGNOR-266436
CHUK	CYLD	Ser418 View in OncoXplorer	TTENRFHsLPFSLTK	phosphorylation down-regulates activity	24614225	SIGNOR-204688
IKBKB	CYLD	Ser418 View in OncoXplorer	TTENRFHsLPFSLTK	phosphorylation down-regulates activity	24614225	SIGNOR-204716
CAMK2B	CYLD	Ser418 View in OncoXplorer	TTENRFHsLPFSLTK	phosphorylation up-regulates activity	24614225	SIGNOR-25329
IKK-complex	CYLD	Ser418 View in OncoXplorer	TTENRFHsLPFSLTK	phosphorylation down-regulates activity	15870263	SIGNOR-266435

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
IKBKE	phosphorylation up-regulates →	CYLD PSer418	phosphorylation down-regulates ⊣	CYLD	19481526	SIGNOR-278311
IKBKB	phosphorylation up-regulates →	CYLD PSer418	phosphorylation down-regulates ⊣	CYLD	15870263	SIGNOR-266436
CHUK	phosphorylation up-regulates →	CYLD PSer418	phosphorylation down-regulates ⊣	CYLD	24614225	SIGNOR-204688
IKBKB	phosphorylation up-regulates →	CYLD PSer418	phosphorylation down-regulates ⊣	CYLD	24614225	SIGNOR-204716
CAMK2B	phosphorylation up-regulates →	CYLD PSer418	phosphorylation up-regulates →	CYLD	24614225	SIGNOR-25329
IKK-complex	phosphorylation up-regulates →	CYLD PSer418	phosphorylation down-regulates ⊣	CYLD	15870263	SIGNOR-266435

Regulator	Mechanism/Effect	Target	SIGNOR-ID
IKBKE	phosphorylation → down-regulates activity	CYLD	SIGNOR-278311
IKBKB	phosphorylation → down-regulates activity	CYLD	SIGNOR-266436
CHUK	phosphorylation → down-regulates activity	CYLD	SIGNOR-204688
IKBKB	phosphorylation → down-regulates activity	CYLD	SIGNOR-204716
CAMK2B	phosphorylation → up-regulates activity	CYLD	SIGNOR-25329
IKK-complex	phosphorylation → down-regulates activity	CYLD	SIGNOR-266435