| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| IKBKB | CYLD | Ser436 | TNGSIGHsPLSLSAQ | phosphorylation down-regulates activity | 24614225 | SIGNOR-204728 |
| CHUK | CYLD | Ser436 | TNGSIGHsPLSLSAQ | phosphorylation down-regulates activity | 24614225 | SIGNOR-204700 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| IKBKB | phosphorylation up-regulates → | CYLD PSer436 | phosphorylation down-regulates ⊣ | CYLD | 24614225 | SIGNOR-204728 |
| CHUK | phosphorylation up-regulates → | CYLD PSer436 | phosphorylation down-regulates ⊣ | CYLD | 24614225 | SIGNOR-204700 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| IKBKB | phosphorylation → down-regulates activity | CYLD | SIGNOR-204728 |
| CHUK | phosphorylation → down-regulates activity | CYLD | SIGNOR-204700 |