| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CHUK | CYLD | Ser439 | SIGHSPLsLSAQSVM | phosphorylation down-regulates activity | 24614225 | SIGNOR-204704 |
| IKBKB | CYLD | Ser439 | SIGHSPLsLSAQSVM | phosphorylation down-regulates activity | 24614225 | SIGNOR-204732 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CHUK | phosphorylation up-regulates → | CYLD PSer439 | phosphorylation down-regulates ⊣ | CYLD | 24614225 | SIGNOR-204704 |
| IKBKB | phosphorylation up-regulates → | CYLD PSer439 | phosphorylation down-regulates ⊣ | CYLD | 24614225 | SIGNOR-204732 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CHUK | phosphorylation → down-regulates activity | CYLD | SIGNOR-204704 |
| IKBKB | phosphorylation → down-regulates activity | CYLD | SIGNOR-204732 |