| Name | SPHK2 |
| ID | Q9NRA0 |
| Role | substrate |
| Enzymatic Domains |
DAGKc 178-325 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK1 | SPHK2 | Thr614 | AFRLEPLtPRGVLTV | phosphorylation up-regulates | 17311928 | SIGNOR-153383 |
| ERK1/2 | SPHK2 | – | phosphorylation up-regulates | 17311928 | SIGNOR-270154 | |
| MAPK3 | SPHK2 | Ser387 | PATVEPAsPTPAHSL | phosphorylation up-regulates | 17311928 | SIGNOR-153387 |
| Gbeta | SPHK2 | – | phosphorylation up-regulates | 17311928 | SIGNOR-270036 | |
| MAPK1 | SPHK2 | Ser387 | PATVEPAsPTPAHSL | phosphorylation up-regulates | 17311928 | SIGNOR-153379 |
| MAPK3 | SPHK2 | Thr614 | AFRLEPLtPRGVLTV | phosphorylation up-regulates | 17311928 | SIGNOR-153391 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK1 | phosphorylation up-regulates → | SPHK2 PThr614 | phosphorylation up-regulates → | SPHK2 | 17311928 | SIGNOR-153383 |
| MAPK3 | phosphorylation up-regulates → | SPHK2 PSer387 | phosphorylation up-regulates → | SPHK2 | 17311928 | SIGNOR-153387 |
| MAPK1 | phosphorylation up-regulates → | SPHK2 PSer387 | phosphorylation up-regulates → | SPHK2 | 17311928 | SIGNOR-153379 |
| MAPK3 | phosphorylation up-regulates → | SPHK2 PThr614 | phosphorylation up-regulates → | SPHK2 | 17311928 | SIGNOR-153391 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK1 | phosphorylation → up-regulates | SPHK2 | SIGNOR-153383 |
| ERK1/2 | phosphorylation → up-regulates | SPHK2 | SIGNOR-270154 |
| MAPK3 | phosphorylation → up-regulates | SPHK2 | SIGNOR-153387 |
| Gbeta | phosphorylation → up-regulates | SPHK2 | SIGNOR-270036 |
| MAPK1 | phosphorylation → up-regulates | SPHK2 | SIGNOR-153379 |
| MAPK3 | phosphorylation → up-regulates | SPHK2 | SIGNOR-153391 |