| Name | LATS2 |
| ID | Q9NRM7 |
| Role | kinase |
| Enzymatic Domains |
UBA 98-139 PROSITE-ProRule
Protein kinase 668-973 PROSITE-ProRule
AGC-kinase C-terminal 974-1052 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| LATS2 | SNAI1 | Thr203 | QGHVRTHtGEKPFSC | phosphorylation up-regulates | 21952048 | SIGNOR-176647 |
| LATS2 | SNAI1 | – | phosphorylation up-regulates quantity by stabilization | 24157836 | SIGNOR-272138 | |
| LATS2 | ABL1 | Thr178 | VYHYRINtASDGKLY | phosphorylation down-regulates activity | 23852372 | SIGNOR-276497 |
| LATS2 | PRPS2 | Thr285 | EDKMKHCtKIQVIDI | phosphorylation down-regulates quantity by destabilization | 34465890 | SIGNOR-276507 |
| LATS2 | CDKN1A | Ser146 | GRKRRQTsMTDFYHS | phosphorylation down-regulates quantity | 23886938 | SIGNOR-279530 |
| LATS2 | YAP1 | Ser127 | PQHVRAHsSPASLQL | phosphorylation down-regulates | 22658639 | SIGNOR-197655 |
| LATS2 | YAP1 | Ser127 | PQHVRAHsSPASLQL | phosphorylation down-regulates | 22863277 | SIGNOR-198514 |
| LATS2 | YAP1 | Ser397 | TYHSRDEsTDSGLSM | phosphorylation down-regulates quantity by destabilization | 20048001 | SIGNOR-218038 |
| LATS2 | PRPS1 | Ser285 | EDKMKHCsKIQVIDI | phosphorylation down-regulates quantity by destabilization | 34465890 | SIGNOR-276504 |
| LATS2 | YWHAG | Ser59 | VVGARRSsWRVISSI | phosphorylation up-regulates | 21118956 | SIGNOR-170139 |
| LATS2 | YWHAG | Ser59 | VVGARRSsWRVISSI | phosphorylation up-regulates | 25086053 | SIGNOR-205247 |
| LATS2 | MTF1 | Ser152 | EGCPRTYsTAGNLRT | phosphorylation down-regulates activity | 35027733 | SIGNOR-275475 |
| LATS2 | AMOT | Ser175 | QGHVRSLsERLMQMS | phosphorylation up-regulates quantity by stabilization | 24101513 | SIGNOR-275846 |
| LATS2 | CDC26 | Thr7 | tRLELKLD | phosphorylation up-regulates activity | 25723520 | SIGNOR-275474 |
| LATS2 | WWTR1 | Ser89 | AQHVRSHsSPASLQL | phosphorylation down-regulates | 21808241 | SIGNOR-175787 |
| LATS2 | WWTR1 | Ser89 | AQHVRSHsSPASLQL | phosphorylation down-regulates | 22658639 | SIGNOR-197651 |
| LATS2 | AMOTL2 | Ser159 | HGHVRSLsERLLQLS | phosphorylation down-regulates activity | 24225952 | SIGNOR-272084 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| LATS2 | phosphorylation up-regulates → | SNAI1 PThr203 | phosphorylation up-regulates → | SNAI1 | 21952048 | SIGNOR-176647 |
| LATS2 | phosphorylation up-regulates → | ABL1 PThr178 | phosphorylation down-regulates ⊣ | ABL1 | 23852372 | SIGNOR-276497 |
| LATS2 | phosphorylation up-regulates → | PRPS2 PThr285 | phosphorylation down-regulates ⊣ | PRPS2 | 34465890 | SIGNOR-276507 |
| LATS2 | phosphorylation up-regulates → | CDKN1A PSer146 | phosphorylation down-regulates ⊣ | CDKN1A | 23886938 | SIGNOR-279530 |
| LATS2 | phosphorylation up-regulates → | YAP1 PSer127 | phosphorylation down-regulates ⊣ | YAP1 | 22658639 | SIGNOR-197655 |
| LATS2 | phosphorylation up-regulates → | YAP1 PSer127 | phosphorylation down-regulates ⊣ | YAP1 | 22863277 | SIGNOR-198514 |
| LATS2 | phosphorylation up-regulates → | YAP1 PSer397 | phosphorylation down-regulates ⊣ | YAP1 | 20048001 | SIGNOR-218038 |
| LATS2 | phosphorylation up-regulates → | PRPS1 PSer285 | phosphorylation down-regulates ⊣ | PRPS1 | 34465890 | SIGNOR-276504 |
| LATS2 | phosphorylation up-regulates → | YWHAG PSer59 | phosphorylation up-regulates → | YWHAG | 21118956 | SIGNOR-170139 |
| LATS2 | phosphorylation up-regulates → | YWHAG PSer59 | phosphorylation up-regulates → | YWHAG | 25086053 | SIGNOR-205247 |
| LATS2 | phosphorylation up-regulates → | MTF1 PSer152 | phosphorylation down-regulates ⊣ | MTF1 | 35027733 | SIGNOR-275475 |
| LATS2 | phosphorylation up-regulates → | AMOT PSer175 | phosphorylation up-regulates → | AMOT | 24101513 | SIGNOR-275846 |
| LATS2 | phosphorylation up-regulates → | CDC26 PThr7 | phosphorylation up-regulates → | CDC26 | 25723520 | SIGNOR-275474 |
| LATS2 | phosphorylation up-regulates → | WWTR1 PSer89 | phosphorylation down-regulates ⊣ | WWTR1 | 21808241 | SIGNOR-175787 |
| LATS2 | phosphorylation up-regulates → | WWTR1 PSer89 | phosphorylation down-regulates ⊣ | WWTR1 | 22658639 | SIGNOR-197651 |
| LATS2 | phosphorylation up-regulates → | AMOTL2 PSer159 | phosphorylation down-regulates ⊣ | AMOTL2 | 24225952 | SIGNOR-272084 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| LATS2 | phosphorylation → up-regulates | SNAI1 | SIGNOR-176647 |
| LATS2 | phosphorylation → up-regulates quantity by stabilization | SNAI1 | SIGNOR-272138 |
| LATS2 | phosphorylation → down-regulates activity | ABL1 | SIGNOR-276497 |
| LATS2 | phosphorylation down-regulates quantity by destabilization | PRPS2 | SIGNOR-276507 |
| LATS2 | phosphorylation → down-regulates quantity | CDKN1A | SIGNOR-279530 |
| LATS2 | phosphorylation down-regulates | YAP1 | SIGNOR-197655 |
| LATS2 | phosphorylation down-regulates | YAP1 | SIGNOR-198514 |
| LATS2 | phosphorylation down-regulates quantity by destabilization | YAP1 | SIGNOR-218038 |
| LATS2 | phosphorylation down-regulates quantity by destabilization | PRPS1 | SIGNOR-276504 |
| LATS2 | phosphorylation → up-regulates | YWHAG | SIGNOR-170139 |
| LATS2 | phosphorylation → up-regulates | YWHAG | SIGNOR-205247 |
| LATS2 | phosphorylation → down-regulates activity | MTF1 | SIGNOR-275475 |
| LATS2 | phosphorylation → up-regulates quantity by stabilization | AMOT | SIGNOR-275846 |
| LATS2 | phosphorylation → up-regulates activity | CDC26 | SIGNOR-275474 |
| LATS2 | phosphorylation down-regulates | WWTR1 | SIGNOR-175787 |
| LATS2 | phosphorylation down-regulates | WWTR1 | SIGNOR-197651 |
| LATS2 | phosphorylation → down-regulates activity | AMOTL2 | SIGNOR-272084 |