| Name | ARHGAP35 |
| ID | Q9NRY4 |
| Role | substrate |
| Enzymatic Domains |
FF 1 270-327
FF 2 368-422
FF 3 429-483
FF 4 485-550
pG1 pseudoGTPase 592-767 PROSITE-ProRule
pG2 pseudoGTPase 783-947 PROSITE-ProRule
Rho-GAP 1249-1436 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPRZ1 | ARHGAP35 | Tyr1105 | RNEEENIySVPHDST | dephosphorylation down-regulates activity | 16513268 | SIGNOR-248451 |
| ROCK1 | ARHGAP35 | Ser1150 | LERGRKVsIVSKPVL | phosphorylation down-regulates | 19103606 | SIGNOR-182849 |
| ROCK1 | ARHGAP35 | Thr1226 | LRSLRRNtKKPKPKP | phosphorylation down-regulates activity | 19103606 | SIGNOR-276178 |
| ROCK1 | ARHGAP35 | Ser1236 | PKPKPRPsITKATWE | phosphorylation down-regulates activity | 19103606 | SIGNOR-276176 |
| ROCK1 | ARHGAP35 | Ser1150 | LERGRKVsIVSKPVL | phosphorylation down-regulates activity | 19103606 | SIGNOR-276177 |
| ROCK1 | ARHGAP35 | Ser1236 | PKPKPRPsITKATWE | phosphorylation down-regulates | 19103606 | SIGNOR-182853 |
| SRC | ARHGAP35 | Tyr1105 | RNEEENIySVPHDST | phosphorylation up-regulates | 9819392 | SIGNOR-61670 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPRZ1 | dephosphorylation down-regulates ⊣ | ARHGAP35 PTyr1105 | dephosphorylation up-regulates → | ARHGAP35 | 16513268 | SIGNOR-248451 |
| ROCK1 | phosphorylation up-regulates → | ARHGAP35 PSer1150 | phosphorylation down-regulates ⊣ | ARHGAP35 | 19103606 | SIGNOR-182849 |
| ROCK1 | phosphorylation up-regulates → | ARHGAP35 PThr1226 | phosphorylation down-regulates ⊣ | ARHGAP35 | 19103606 | SIGNOR-276178 |
| ROCK1 | phosphorylation up-regulates → | ARHGAP35 PSer1236 | phosphorylation down-regulates ⊣ | ARHGAP35 | 19103606 | SIGNOR-276176 |
| ROCK1 | phosphorylation up-regulates → | ARHGAP35 PSer1150 | phosphorylation down-regulates ⊣ | ARHGAP35 | 19103606 | SIGNOR-276177 |
| ROCK1 | phosphorylation up-regulates → | ARHGAP35 PSer1236 | phosphorylation down-regulates ⊣ | ARHGAP35 | 19103606 | SIGNOR-182853 |
| SRC | phosphorylation up-regulates → | ARHGAP35 PTyr1105 | phosphorylation up-regulates → | ARHGAP35 | 9819392 | SIGNOR-61670 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTPRZ1 | dephosphorylation → down-regulates activity | ARHGAP35 | SIGNOR-248451 |
| ROCK1 | phosphorylation down-regulates | ARHGAP35 | SIGNOR-182849 |
| ROCK1 | phosphorylation → down-regulates activity | ARHGAP35 | SIGNOR-276178 |
| ROCK1 | phosphorylation → down-regulates activity | ARHGAP35 | SIGNOR-276176 |
| ROCK1 | phosphorylation → down-regulates activity | ARHGAP35 | SIGNOR-276177 |
| ROCK1 | phosphorylation down-regulates | ARHGAP35 | SIGNOR-182853 |
| SRC | phosphorylation → up-regulates | ARHGAP35 | SIGNOR-61670 |