Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
CyclinB/CDK1	SIRT3	Thr150	MVGAGIStPSGIPDF	phosphorylation up-regulates activity	26141949	SIGNOR-276922
FLT3	SIRT3	Tyr226	KGLLLRLyTQNIDGL	phosphorylation down-regulates activity	34289383	SIGNOR-267631
CDK1	SIRT3	Thr150	MVGAGIStPSGIPDF	phosphorylation up-regulates activity	26141949	SIGNOR-279395
CDK1	SIRT3	Ser159	SGIPDFRsPGSGLYS	phosphorylation up-regulates activity	26141949	SIGNOR-279396
CyclinB/CDK1	SIRT3	Ser159	SGIPDFRsPGSGLYS	phosphorylation up-regulates activity	26141949	SIGNOR-276921

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
CyclinB/CDK1	phosphorylation up-regulates →	SIRT3 PThr150	phosphorylation up-regulates →	SIRT3	26141949	SIGNOR-276922
FLT3	phosphorylation up-regulates →	SIRT3 PTyr226	phosphorylation down-regulates ⊣	SIRT3	34289383	SIGNOR-267631
CDK1	phosphorylation up-regulates →	SIRT3 PThr150	phosphorylation up-regulates →	SIRT3	26141949	SIGNOR-279395
CDK1	phosphorylation up-regulates →	SIRT3 PSer159	phosphorylation up-regulates →	SIRT3	26141949	SIGNOR-279396
CyclinB/CDK1	phosphorylation up-regulates →	SIRT3 PSer159	phosphorylation up-regulates →	SIRT3	26141949	SIGNOR-276921

Regulator	Mechanism/Effect	Target	SIGNOR-ID
CyclinB/CDK1	phosphorylation → up-regulates activity	SIRT3	SIGNOR-276922
FLT3	phosphorylation → down-regulates activity	SIRT3	SIGNOR-267631
CDK1	phosphorylation → up-regulates activity	SIRT3	SIGNOR-279395
CDK1	phosphorylation → up-regulates activity	SIRT3	SIGNOR-279396
CyclinB/CDK1	phosphorylation → up-regulates activity	SIRT3	SIGNOR-276921