Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
IRAK4	NCF1	Ser288	QKSGQDVsQAQRQIK	phosphorylation up-regulates	17217339	SIGNOR-152011
IRAK4	NCF1	Ser320	QRSRKRLsQDAYRRN	phosphorylation up-regulates	17217339	SIGNOR-152015
IRAK4	NCF1	Ser345	QARPGPQsPGSPLEE	phosphorylation up-regulates	17217339	SIGNOR-152019
IRAK4	NCF1	Thr133	KLPTDNQtKKPETYL	phosphorylation up-regulates	17217339	SIGNOR-152023
IRAK4	NCF1	Thr356	PLEEERQtQRSKPQP	phosphorylation up-regulates	17217339	SIGNOR-152027
IRAK4	IRAK1	Ser376	GSSPSQSsMVARTQT	phosphorylation up-regulates activity	11960013	SIGNOR-251328
IRAK4	IRAK1	Thr387	RTQTVRGtLAYLPEE	phosphorylation up-regulates activity	11960013	SIGNOR-251329
IRAK4	IRAK1	–		phosphorylation up-regulates activity	11960013	SIGNOR-117315
IRAK4	IRAK1	–		phosphorylation up-regulates activity	17337443	SIGNOR-153458
IRAK4	PELI1	Ser293	FNTLAFPsMKRKDVV	phosphorylation up-regulates activity	19264966	SIGNOR-276130
IRAK4	PELI1	Ser76	ISNKDQHsISYTLSR	phosphorylation up-regulates activity	19264966	SIGNOR-276127
IRAK4	PELI1	Ser78	NKDQHSIsYTLSRAQ	phosphorylation up-regulates activity	19264966	SIGNOR-276126
IRAK4	PELI1	Ser82	HSISYTLsRAQTVVV	phosphorylation up-regulates activity	19264966	SIGNOR-276132
IRAK4	PELI1	Thr288	QCPVGFNtLAFPSMK	phosphorylation up-regulates activity	19264966	SIGNOR-276129
IRAK4	PELI1	Thr80	DQHSISYtLSRAQTV	phosphorylation up-regulates activity	19264966	SIGNOR-276131
IRAK4	PELI1	Thr86	YTLSRAQtVVVEYTH	phosphorylation up-regulates activity	19264966	SIGNOR-276128
IRAK4	PELI2	–		phosphorylation up-regulates	12860405	SIGNOR-103717
IRAK4	IRAK4	Thr342	ASEKFAQtVMTSRIV	phosphorylation up-regulates activity	17141195	SIGNOR-151006
IRAK4	IRAK4	Ser346	FAQTVMTsRIVGTTA	phosphorylation up-regulates activity	24567333	SIGNOR-204653
IRAK4	IRAK4	Thr342	ASEKFAQtVMTSRIV	phosphorylation up-regulates activity	24567333	SIGNOR-204657
IRAK4	IRAK4	Thr345	KFAQTVMtSRIVGTT	phosphorylation up-regulates activity	24567333	SIGNOR-204661

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
IRAK4	phosphorylation up-regulates →	NCF1 PSer288	phosphorylation up-regulates →	NCF1	17217339	SIGNOR-152011
IRAK4	phosphorylation up-regulates →	NCF1 PSer320	phosphorylation up-regulates →	NCF1	17217339	SIGNOR-152015
IRAK4	phosphorylation up-regulates →	NCF1 PSer345	phosphorylation up-regulates →	NCF1	17217339	SIGNOR-152019
IRAK4	phosphorylation up-regulates →	NCF1 PThr133	phosphorylation up-regulates →	NCF1	17217339	SIGNOR-152023
IRAK4	phosphorylation up-regulates →	NCF1 PThr356	phosphorylation up-regulates →	NCF1	17217339	SIGNOR-152027
IRAK4	phosphorylation up-regulates →	IRAK1 PSer376	phosphorylation up-regulates →	IRAK1	11960013	SIGNOR-251328
IRAK4	phosphorylation up-regulates →	IRAK1 PThr387	phosphorylation up-regulates →	IRAK1	11960013	SIGNOR-251329
IRAK4	phosphorylation up-regulates →	PELI1 PSer293	phosphorylation up-regulates →	PELI1	19264966	SIGNOR-276130
IRAK4	phosphorylation up-regulates →	PELI1 PSer76	phosphorylation up-regulates →	PELI1	19264966	SIGNOR-276127
IRAK4	phosphorylation up-regulates →	PELI1 PSer78	phosphorylation up-regulates →	PELI1	19264966	SIGNOR-276126
IRAK4	phosphorylation up-regulates →	PELI1 PSer82	phosphorylation up-regulates →	PELI1	19264966	SIGNOR-276132
IRAK4	phosphorylation up-regulates →	PELI1 PThr288	phosphorylation up-regulates →	PELI1	19264966	SIGNOR-276129
IRAK4	phosphorylation up-regulates →	PELI1 PThr80	phosphorylation up-regulates →	PELI1	19264966	SIGNOR-276131
IRAK4	phosphorylation up-regulates →	PELI1 PThr86	phosphorylation up-regulates →	PELI1	19264966	SIGNOR-276128
IRAK4	phosphorylation up-regulates →	IRAK4 PThr342	phosphorylation up-regulates →	IRAK4	17141195	SIGNOR-151006
IRAK4	phosphorylation up-regulates →	IRAK4 PSer346	phosphorylation up-regulates →	IRAK4	24567333	SIGNOR-204653
IRAK4	phosphorylation up-regulates →	IRAK4 PThr342	phosphorylation up-regulates →	IRAK4	24567333	SIGNOR-204657
IRAK4	phosphorylation up-regulates →	IRAK4 PThr345	phosphorylation up-regulates →	IRAK4	24567333	SIGNOR-204661

Regulator	Mechanism/Effect	Target	SIGNOR-ID
IRAK4	phosphorylation → up-regulates	NCF1	SIGNOR-152011
IRAK4	phosphorylation → up-regulates	NCF1	SIGNOR-152015
IRAK4	phosphorylation → up-regulates	NCF1	SIGNOR-152019
IRAK4	phosphorylation → up-regulates	NCF1	SIGNOR-152023
IRAK4	phosphorylation → up-regulates	NCF1	SIGNOR-152027
IRAK4	phosphorylation → up-regulates activity	IRAK1	SIGNOR-251328
IRAK4	phosphorylation → up-regulates activity	IRAK1	SIGNOR-251329
IRAK4	phosphorylation → up-regulates activity	IRAK1	SIGNOR-117315
IRAK4	phosphorylation → up-regulates activity	IRAK1	SIGNOR-153458
IRAK4	phosphorylation → up-regulates activity	PELI1	SIGNOR-276130
IRAK4	phosphorylation → up-regulates activity	PELI1	SIGNOR-276127
IRAK4	phosphorylation → up-regulates activity	PELI1	SIGNOR-276126
IRAK4	phosphorylation → up-regulates activity	PELI1	SIGNOR-276132
IRAK4	phosphorylation → up-regulates activity	PELI1	SIGNOR-276129
IRAK4	phosphorylation → up-regulates activity	PELI1	SIGNOR-276131
IRAK4	phosphorylation → up-regulates activity	PELI1	SIGNOR-276128
IRAK4	phosphorylation → up-regulates	PELI2	SIGNOR-103717
IRAK4	phosphorylation → up-regulates activity	IRAK4	SIGNOR-151006
IRAK4	phosphorylation → up-regulates activity	IRAK4	SIGNOR-204653
IRAK4	phosphorylation → up-regulates activity	IRAK4	SIGNOR-204657
IRAK4	phosphorylation → up-regulates activity	IRAK4	SIGNOR-204661