| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CyclinB/CDK1 | NDE1 | Thr215 | ATGSVPStPIAHRGP | phosphorylation up-regulates quantity by stabilization | 16682949 | SIGNOR-274082 |
| MAPK1 | NDE1 | Ser239 | FRRGLDDsTGGTPLT | phosphorylation up-regulates activity | 12556484 | SIGNOR-249421 |
| CyclinB/CDK1 | NDE1 | Ser282 | RNLVYDQsPNRTGGP | phosphorylation up-regulates quantity by stabilization | 16682949 | SIGNOR-274083 |
| CyclinB/CDK1 | NDE1 | Thr246 | STGGTPLtPAARISA | phosphorylation up-regulates quantity by stabilization | 16682949 | SIGNOR-274086 |
| CyclinB/CDK1 | NDE1 | Thr191 | QKQEKPRtPMPSSVE | phosphorylation up-regulates quantity by stabilization | 16682949 | SIGNOR-274087 |
| MAPK1 | NDE1 | Thr215 | ATGSVPStPIAHRGP | phosphorylation up-regulates activity | 12556484 | SIGNOR-249422 |
| CDK1 | NDE1 | – | phosphorylation up-regulates | 16682949 | SIGNOR-146734 | |
| PRKACA | NDE1 | Thr131 | LERAKRAtIMSLEDF | phosphorylation up-regulates | 21677187 | SIGNOR-174410 |
| MAPK1 | NDE1 | – | phosphorylation up-regulates activity | 12556484 | SIGNOR-274078 | |
| CyclinB/CDK1 | NDE1 | Thr243 | LDDSTGGtPLTPAAR | phosphorylation up-regulates quantity by stabilization | 16682949 | SIGNOR-274084 |
| CyclinB/CDK1 | NDE1 | Thr228 | GPSSSLNtPGSFRRG | phosphorylation up-regulates quantity by stabilization | 16682949 | SIGNOR-274085 |
| CDK1 | NDE1 | – | phosphorylation up-regulates activity | 12556484 | SIGNOR-274077 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CyclinB/CDK1 | phosphorylation up-regulates → | NDE1 PThr215 | phosphorylation up-regulates → | NDE1 | 16682949 | SIGNOR-274082 |
| MAPK1 | phosphorylation up-regulates → | NDE1 PSer239 | phosphorylation up-regulates → | NDE1 | 12556484 | SIGNOR-249421 |
| CyclinB/CDK1 | phosphorylation up-regulates → | NDE1 PSer282 | phosphorylation up-regulates → | NDE1 | 16682949 | SIGNOR-274083 |
| CyclinB/CDK1 | phosphorylation up-regulates → | NDE1 PThr246 | phosphorylation up-regulates → | NDE1 | 16682949 | SIGNOR-274086 |
| CyclinB/CDK1 | phosphorylation up-regulates → | NDE1 PThr191 | phosphorylation up-regulates → | NDE1 | 16682949 | SIGNOR-274087 |
| MAPK1 | phosphorylation up-regulates → | NDE1 PThr215 | phosphorylation up-regulates → | NDE1 | 12556484 | SIGNOR-249422 |
| PRKACA | phosphorylation up-regulates → | NDE1 PThr131 | phosphorylation up-regulates → | NDE1 | 21677187 | SIGNOR-174410 |
| CyclinB/CDK1 | phosphorylation up-regulates → | NDE1 PThr243 | phosphorylation up-regulates → | NDE1 | 16682949 | SIGNOR-274084 |
| CyclinB/CDK1 | phosphorylation up-regulates → | NDE1 PThr228 | phosphorylation up-regulates → | NDE1 | 16682949 | SIGNOR-274085 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CyclinB/CDK1 | phosphorylation → up-regulates quantity by stabilization | NDE1 | SIGNOR-274082 |
| MAPK1 | phosphorylation → up-regulates activity | NDE1 | SIGNOR-249421 |
| CyclinB/CDK1 | phosphorylation → up-regulates quantity by stabilization | NDE1 | SIGNOR-274083 |
| CyclinB/CDK1 | phosphorylation → up-regulates quantity by stabilization | NDE1 | SIGNOR-274086 |
| CyclinB/CDK1 | phosphorylation → up-regulates quantity by stabilization | NDE1 | SIGNOR-274087 |
| MAPK1 | phosphorylation → up-regulates activity | NDE1 | SIGNOR-249422 |
| CDK1 | phosphorylation → up-regulates | NDE1 | SIGNOR-146734 |
| PRKACA | phosphorylation → up-regulates | NDE1 | SIGNOR-174410 |
| MAPK1 | phosphorylation → up-regulates activity | NDE1 | SIGNOR-274078 |
| CyclinB/CDK1 | phosphorylation → up-regulates quantity by stabilization | NDE1 | SIGNOR-274084 |
| CyclinB/CDK1 | phosphorylation → up-regulates quantity by stabilization | NDE1 | SIGNOR-274085 |
| CDK1 | phosphorylation → up-regulates activity | NDE1 | SIGNOR-274077 |
