| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CHEK2 | AATF | Ser477 | ELIERKTsSLDPNDQ | phosphorylation up-regulates quantity by stabilization | 17157788 | SIGNOR-264417 |
| ATM | AATF | Ser189 | EGDDAEDsQGESEED | phosphorylation up-regulates quantity by stabilization | 17157788 | SIGNOR-264415 |
| HIPK2 | AATF | – | phosphorylation down-regulates quantity | 25210797 | SIGNOR-278942 | |
| CHEK2 | AATF | Ser143 | SKKSRSHsAKTPGFS | phosphorylation up-regulates quantity by stabilization | 17157788 | SIGNOR-264416 |
| CHEK2 | AATF | Ser510 | KKVDRKAsKGRKLRF | phosphorylation up-regulates quantity by stabilization | 17157788 | SIGNOR-264418 |
| MAPKAPK2 | AATF | Thr366 | FTVYRNRtLQKWHDK | phosphorylation up-regulates | 22909821 | SIGNOR-191935 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CHEK2 | phosphorylation up-regulates → | AATF PSer477 | phosphorylation up-regulates → | AATF | 17157788 | SIGNOR-264417 |
| ATM | phosphorylation up-regulates → | AATF PSer189 | phosphorylation up-regulates → | AATF | 17157788 | SIGNOR-264415 |
| CHEK2 | phosphorylation up-regulates → | AATF PSer143 | phosphorylation up-regulates → | AATF | 17157788 | SIGNOR-264416 |
| CHEK2 | phosphorylation up-regulates → | AATF PSer510 | phosphorylation up-regulates → | AATF | 17157788 | SIGNOR-264418 |
| MAPKAPK2 | phosphorylation up-regulates → | AATF PThr366 | phosphorylation up-regulates → | AATF | 22909821 | SIGNOR-191935 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CHEK2 | phosphorylation → up-regulates quantity by stabilization | AATF | SIGNOR-264417 |
| ATM | phosphorylation → up-regulates quantity by stabilization | AATF | SIGNOR-264415 |
| HIPK2 | phosphorylation → down-regulates quantity | AATF | SIGNOR-278942 |
| CHEK2 | phosphorylation → up-regulates quantity by stabilization | AATF | SIGNOR-264416 |
| CHEK2 | phosphorylation → up-regulates quantity by stabilization | AATF | SIGNOR-264418 |
| MAPKAPK2 | phosphorylation → up-regulates | AATF | SIGNOR-191935 |