| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK3 | RRN3 | Ser649 | PVLYMQPsPL | phosphorylation up-regulates | 12620228 | SIGNOR-98984 |
| CSNK2A1 | RRN3 | Ser172 | GDVDVSDsDDEDDNL | phosphorylation down-regulates | 18559419 | SIGNOR-178943 |
| CSNK2A1 | RRN3 | Ser170 | KEGDVDVsDSDDEDD | phosphorylation down-regulates | 18559419 | SIGNOR-178939 |
| CDK2 | RRN3 | Ser44 | LENDFFNsPPRKTVR | phosphorylation up-regulates | 15004009 | SIGNOR-123231 |
| MAPK3 | RRN3 | Ser633 | SFDTHFRsPSSSVGS | phosphorylation up-regulates | 12620228 | SIGNOR-98980 |
| MAPK9 | RRN3 | Thr200 | IARYVPStPWFLMPI | phosphorylation down-regulates | 15805466 | SIGNOR-134878 |
| CyclinE/CDK2 | RRN3 | Ser44 | LENDFFNsPPRKTVR | phosphorylation up-regulates | 15004009 | SIGNOR-216682 |
| AMPK | RRN3 | Ser635 | DTHFRSPsSSVGSPP | phosphorylation down-regulates | 19815529 | SIGNOR-216592 |
| PRKAA1 | RRN3 | Ser635 | DTHFRSPsSSVGSPP | phosphorylation down-regulates | 19815529 | SIGNOR-188403 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK3 | phosphorylation up-regulates → | RRN3 PSer649 | phosphorylation up-regulates → | RRN3 | 12620228 | SIGNOR-98984 |
| CSNK2A1 | phosphorylation up-regulates → | RRN3 PSer172 | phosphorylation down-regulates ⊣ | RRN3 | 18559419 | SIGNOR-178943 |
| CSNK2A1 | phosphorylation up-regulates → | RRN3 PSer170 | phosphorylation down-regulates ⊣ | RRN3 | 18559419 | SIGNOR-178939 |
| CDK2 | phosphorylation up-regulates → | RRN3 PSer44 | phosphorylation up-regulates → | RRN3 | 15004009 | SIGNOR-123231 |
| MAPK3 | phosphorylation up-regulates → | RRN3 PSer633 | phosphorylation up-regulates → | RRN3 | 12620228 | SIGNOR-98980 |
| MAPK9 | phosphorylation up-regulates → | RRN3 PThr200 | phosphorylation down-regulates ⊣ | RRN3 | 15805466 | SIGNOR-134878 |
| CyclinE/CDK2 | phosphorylation up-regulates → | RRN3 PSer44 | phosphorylation up-regulates → | RRN3 | 15004009 | SIGNOR-216682 |
| AMPK | phosphorylation up-regulates → | RRN3 PSer635 | phosphorylation down-regulates ⊣ | RRN3 | 19815529 | SIGNOR-216592 |
| PRKAA1 | phosphorylation up-regulates → | RRN3 PSer635 | phosphorylation down-regulates ⊣ | RRN3 | 19815529 | SIGNOR-188403 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK3 | phosphorylation → up-regulates | RRN3 | SIGNOR-98984 |
| CSNK2A1 | phosphorylation down-regulates | RRN3 | SIGNOR-178943 |
| CSNK2A1 | phosphorylation down-regulates | RRN3 | SIGNOR-178939 |
| CDK2 | phosphorylation → up-regulates | RRN3 | SIGNOR-123231 |
| MAPK3 | phosphorylation → up-regulates | RRN3 | SIGNOR-98980 |
| MAPK9 | phosphorylation down-regulates | RRN3 | SIGNOR-134878 |
| CyclinE/CDK2 | phosphorylation → up-regulates | RRN3 | SIGNOR-216682 |
| AMPK | phosphorylation down-regulates | RRN3 | SIGNOR-216592 |
| PRKAA1 | phosphorylation down-regulates | RRN3 | SIGNOR-188403 |
