| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AMPK | RRN3 | Ser635 | DTHFRSPsSSVGSPP | phosphorylation down-regulates | 19815529 | SIGNOR-216592 |
| PRKAA1 | RRN3 | Ser635 | DTHFRSPsSSVGSPP | phosphorylation down-regulates | 19815529 | SIGNOR-188403 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AMPK | phosphorylation up-regulates → | RRN3 PSer635 | phosphorylation down-regulates ⊣ | RRN3 | 19815529 | SIGNOR-216592 |
| PRKAA1 | phosphorylation up-regulates → | RRN3 PSer635 | phosphorylation down-regulates ⊣ | RRN3 | 19815529 | SIGNOR-188403 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| AMPK | phosphorylation![]() down-regulates | RRN3 | SIGNOR-216592 |
| PRKAA1 | phosphorylation![]() down-regulates | RRN3 | SIGNOR-188403 |