Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
EIF2AK3	OGT	–		phosphorylation up-regulates activity	33592173	SIGNOR-279736
EIF2AK3	EIF2S1	Ser52	MILLSELsRRRIRSI	phosphorylation down-regulates	17998206	SIGNOR-159160
EIF2AK3	EIF2S1	Ser52	MILLSELsRRRIRSI	phosphorylation down-regulates activity	25660019	SIGNOR-260874
EIF2AK3	EIF2S1	Ser52	MILLSELsRRRIRSI	phosphorylation down-regulates activity	30070006	SIGNOR-246153
EIF2AK3	EIF2S1	–		phosphorylation down-regulates activity	31226023	SIGNOR-260165
EIF2AK3	DLG4	Thr19	YRYQDEDtPPLEHSP	phosphorylation up-regulates activity	28522733	SIGNOR-280004
EIF2AK3	PPP3CA	–		phosphorylation down-regulates activity	20700529	SIGNOR-278933
EIF2AK3	EIF2AK3	Tyr619	NKVDDCNyAIKRIRL	phosphorylation up-regulates	17998206	SIGNOR-159156

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
EIF2AK3	phosphorylation up-regulates →	EIF2S1 PSer52	phosphorylation down-regulates ⊣	EIF2S1	17998206	SIGNOR-159160
EIF2AK3	phosphorylation up-regulates →	EIF2S1 PSer52	phosphorylation down-regulates ⊣	EIF2S1	25660019	SIGNOR-260874
EIF2AK3	phosphorylation up-regulates →	EIF2S1 PSer52	phosphorylation down-regulates ⊣	EIF2S1	30070006	SIGNOR-246153
EIF2AK3	phosphorylation up-regulates →	DLG4 PThr19	phosphorylation up-regulates →	DLG4	28522733	SIGNOR-280004
EIF2AK3	phosphorylation up-regulates →	EIF2AK3 PTyr619	phosphorylation up-regulates →	EIF2AK3	17998206	SIGNOR-159156

Regulator	Mechanism/Effect	Target	SIGNOR-ID
EIF2AK3	phosphorylation → up-regulates activity	OGT	SIGNOR-279736
EIF2AK3	phosphorylation down-regulates	EIF2S1	SIGNOR-159160
EIF2AK3	phosphorylation → down-regulates activity	EIF2S1	SIGNOR-260874
EIF2AK3	phosphorylation → down-regulates activity	EIF2S1	SIGNOR-246153
EIF2AK3	phosphorylation → down-regulates activity	EIF2S1	SIGNOR-260165
EIF2AK3	phosphorylation → up-regulates activity	DLG4	SIGNOR-280004
EIF2AK3	phosphorylation → down-regulates activity	PPP3CA	SIGNOR-278933
EIF2AK3	phosphorylation → up-regulates	EIF2AK3	SIGNOR-159156