| Name | EIF2AK3 |
| ID | Q9NZJ5 |
| Role | substrate |
| Enzymatic Domains |
Protein kinase 593-1077 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| JAK1 | EIF2AK3 | Tyr585 | NDIKNSGyISRYLTD | phosphorylation up-regulates activity | 25113558 | SIGNOR-276676 |
| PTPN1 | EIF2AK3 | – | dephosphorylation down-regulates activity | 22169477 | SIGNOR-277051 | |
| JAK1 | EIF2AK3 | Tyr619 | NKVDDCNyAIKRIRL | phosphorylation up-regulates activity | 25113558 | SIGNOR-276677 |
| EIF2AK3 | EIF2AK3 | Tyr619 | NKVDDCNyAIKRIRL | phosphorylation up-regulates | 17998206 | SIGNOR-159156 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| JAK1 | phosphorylation up-regulates → | EIF2AK3 PTyr585 | phosphorylation up-regulates → | EIF2AK3 | 25113558 | SIGNOR-276676 |
| JAK1 | phosphorylation up-regulates → | EIF2AK3 PTyr619 | phosphorylation up-regulates → | EIF2AK3 | 25113558 | SIGNOR-276677 |
| EIF2AK3 | phosphorylation up-regulates → | EIF2AK3 PTyr619 | phosphorylation up-regulates → | EIF2AK3 | 17998206 | SIGNOR-159156 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| JAK1 | phosphorylation → up-regulates activity | EIF2AK3 | SIGNOR-276676 |
| PTPN1 | dephosphorylation → down-regulates activity | EIF2AK3 | SIGNOR-277051 |
| JAK1 | phosphorylation → up-regulates activity | EIF2AK3 | SIGNOR-276677 |
| EIF2AK3 | phosphorylation → up-regulates | EIF2AK3 | SIGNOR-159156 |