| Name | PDP1 |
| ID | Q9P0J1 |
| Role | phosphatase |
| Enzymatic Domains |
PPM-type phosphatase 109-525 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PDP1 | PDHA1 | – | dephosphorylation up-regulates activity | 20208177 | SIGNOR-251664 | |
| PDP1 | PDHA1 | Ser232 | NRYGMGTsVERAAAS | dephosphorylation up-regulates activity | 7782287 | SIGNOR-252055 |
| PDP1 | PDHA1 | Ser293 | TYRYHGHsMSDPGVS | dephosphorylation up-regulates activity | 7782287 | SIGNOR-252054 |
| PDP1 | PDHA1 | Ser300 | SMSDPGVsYRTREEI | dephosphorylation up-regulates activity | 7782287 | SIGNOR-252056 |
| PDP1 | SMAD1 | – | dephosphorylation down-regulates | 16510868 | SIGNOR-144876 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PDP1 | dephosphorylation down-regulates ⊣ | PDHA1 PSer232 | dephosphorylation down-regulates ⊣ | PDHA1 | 7782287 | SIGNOR-252055 |
| PDP1 | dephosphorylation down-regulates ⊣ | PDHA1 PSer293 | dephosphorylation down-regulates ⊣ | PDHA1 | 7782287 | SIGNOR-252054 |
| PDP1 | dephosphorylation down-regulates ⊣ | PDHA1 PSer300 | dephosphorylation down-regulates ⊣ | PDHA1 | 7782287 | SIGNOR-252056 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PDP1 | dephosphorylation → up-regulates activity | PDHA1 | SIGNOR-251664 |
| PDP1 | dephosphorylation → up-regulates activity | PDHA1 | SIGNOR-252055 |
| PDP1 | dephosphorylation → up-regulates activity | PDHA1 | SIGNOR-252054 |
| PDP1 | dephosphorylation → up-regulates activity | PDHA1 | SIGNOR-252056 |
| PDP1 | dephosphorylation down-regulates | SMAD1 | SIGNOR-144876 |