| Name | MARK1 |
| ID | Q9P0L2 |
| Role | kinase |
| Enzymatic Domains |
Protein kinase 60-311 PROSITE-ProRule
UBA 325-370 PROSITE-ProRule
KA1 746-795 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MARK1 | MAPT | Ser579 | NVKSKIGsTENLKHQ | phosphorylation down-regulates | 21215781 | SIGNOR-171050 |
| MARK1 | MAPT | Ser641 | KVTSKCGsLGNIHHK | phosphorylation down-regulates | 21215781 | SIGNOR-171054 |
| MARK1 | MAPT | Ser673 | RVQSKIGsLDNITHV | phosphorylation down-regulates | 21215781 | SIGNOR-171058 |
| MARK1 | MAPT | Ser579 | NVKSKIGsTENLKHQ | phosphorylation down-regulates activity | 10090741 | SIGNOR-250172 |
| MARK1 | MAPT | Ser637 | VDLSKVTsKCGSLGN | phosphorylation down-regulates activity | 10090741 | SIGNOR-250173 |
| MARK1 | MAPT | Ser641 | KVTSKCGsLGNIHHK | phosphorylation down-regulates activity | 10090741 | SIGNOR-250174 |
| MARK1 | MAPT | Ser673 | RVQSKIGsLDNITHV | phosphorylation down-regulates activity | 10090741 | SIGNOR-250175 |
| MARK1 | MAP2 | Ser1540 | KSPEKRSsLPRPSSI | phosphorylation down-regulates activity | 8631898 | SIGNOR-250163 |
| MARK1 | MAP2 | Ser1679 | NVKSKIGsTDNIKYQ | phosphorylation down-regulates activity | 8631898 | SIGNOR-250164 |
| MARK1 | MAP2 | Ser1710 | HVTSKCGsLKNIRHR | phosphorylation down-regulates activity | 8631898 | SIGNOR-250165 |
| MARK1 | MAP2 | Ser1795 | VASPRRLsNVSSSGS | phosphorylation down-regulates activity | 8631898 | SIGNOR-250166 |
| MARK1 | MAP2 | Ser1799 | RRLSNVSsSGSINLL | phosphorylation down-regulates activity | 8631898 | SIGNOR-250167 |
| MARK1 | MAP2 | Ser1802 | SNVSSSGsINLLESP | phosphorylation down-regulates activity | 8631898 | SIGNOR-250168 |
| MARK1 | MAP4 | Ser1073 | KAQAKVGsLDNVGHL | phosphorylation down-regulates activity | 8631898 | SIGNOR-250169 |
| MARK1 | MAP4 | Ser928 | SRLATNTsAPDLKNV | phosphorylation down-regulates activity | 8631898 | SIGNOR-250170 |
| MARK1 | MAP4 | Ser941 | NVRSKVGsTENIKHQ | phosphorylation down-regulates activity | 8631898 | SIGNOR-250171 |
| MARK1 | TNK1 | Ser502 | RMKGISRsLESVLSL | phosphorylation down-regulates activity | 34504101 | SIGNOR-273866 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MARK1 | phosphorylation up-regulates → | MAPT PSer579 | phosphorylation down-regulates ⊣ | MAPT | 21215781 | SIGNOR-171050 |
| MARK1 | phosphorylation up-regulates → | MAPT PSer641 | phosphorylation down-regulates ⊣ | MAPT | 21215781 | SIGNOR-171054 |
| MARK1 | phosphorylation up-regulates → | MAPT PSer673 | phosphorylation down-regulates ⊣ | MAPT | 21215781 | SIGNOR-171058 |
| MARK1 | phosphorylation up-regulates → | MAPT PSer579 | phosphorylation down-regulates ⊣ | MAPT | 10090741 | SIGNOR-250172 |
| MARK1 | phosphorylation up-regulates → | MAPT PSer637 | phosphorylation down-regulates ⊣ | MAPT | 10090741 | SIGNOR-250173 |
| MARK1 | phosphorylation up-regulates → | MAPT PSer641 | phosphorylation down-regulates ⊣ | MAPT | 10090741 | SIGNOR-250174 |
| MARK1 | phosphorylation up-regulates → | MAPT PSer673 | phosphorylation down-regulates ⊣ | MAPT | 10090741 | SIGNOR-250175 |
| MARK1 | phosphorylation up-regulates → | MAP2 PSer1540 | phosphorylation down-regulates ⊣ | MAP2 | 8631898 | SIGNOR-250163 |
| MARK1 | phosphorylation up-regulates → | MAP2 PSer1679 | phosphorylation down-regulates ⊣ | MAP2 | 8631898 | SIGNOR-250164 |
| MARK1 | phosphorylation up-regulates → | MAP2 PSer1710 | phosphorylation down-regulates ⊣ | MAP2 | 8631898 | SIGNOR-250165 |
| MARK1 | phosphorylation up-regulates → | MAP2 PSer1795 | phosphorylation down-regulates ⊣ | MAP2 | 8631898 | SIGNOR-250166 |
| MARK1 | phosphorylation up-regulates → | MAP2 PSer1799 | phosphorylation down-regulates ⊣ | MAP2 | 8631898 | SIGNOR-250167 |
| MARK1 | phosphorylation up-regulates → | MAP2 PSer1802 | phosphorylation down-regulates ⊣ | MAP2 | 8631898 | SIGNOR-250168 |
| MARK1 | phosphorylation up-regulates → | MAP4 PSer1073 | phosphorylation down-regulates ⊣ | MAP4 | 8631898 | SIGNOR-250169 |
| MARK1 | phosphorylation up-regulates → | MAP4 PSer928 | phosphorylation down-regulates ⊣ | MAP4 | 8631898 | SIGNOR-250170 |
| MARK1 | phosphorylation up-regulates → | MAP4 PSer941 | phosphorylation down-regulates ⊣ | MAP4 | 8631898 | SIGNOR-250171 |
| MARK1 | phosphorylation up-regulates → | TNK1 PSer502 | phosphorylation down-regulates ⊣ | TNK1 | 34504101 | SIGNOR-273866 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MARK1 | phosphorylation down-regulates | MAPT | SIGNOR-171050 |
| MARK1 | phosphorylation down-regulates | MAPT | SIGNOR-171054 |
| MARK1 | phosphorylation down-regulates | MAPT | SIGNOR-171058 |
| MARK1 | phosphorylation → down-regulates activity | MAPT | SIGNOR-250172 |
| MARK1 | phosphorylation → down-regulates activity | MAPT | SIGNOR-250173 |
| MARK1 | phosphorylation → down-regulates activity | MAPT | SIGNOR-250174 |
| MARK1 | phosphorylation → down-regulates activity | MAPT | SIGNOR-250175 |
| MARK1 | phosphorylation → down-regulates activity | MAP2 | SIGNOR-250163 |
| MARK1 | phosphorylation → down-regulates activity | MAP2 | SIGNOR-250164 |
| MARK1 | phosphorylation → down-regulates activity | MAP2 | SIGNOR-250165 |
| MARK1 | phosphorylation → down-regulates activity | MAP2 | SIGNOR-250166 |
| MARK1 | phosphorylation → down-regulates activity | MAP2 | SIGNOR-250167 |
| MARK1 | phosphorylation → down-regulates activity | MAP2 | SIGNOR-250168 |
| MARK1 | phosphorylation → down-regulates activity | MAP4 | SIGNOR-250169 |
| MARK1 | phosphorylation → down-regulates activity | MAP4 | SIGNOR-250170 |
| MARK1 | phosphorylation → down-regulates activity | MAP4 | SIGNOR-250171 |
| MARK1 | phosphorylation → down-regulates activity | TNK1 | SIGNOR-273866 |