Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
PIM2	NFATC1	–		phosphorylation up-regulates activity	31730483	SIGNOR-276772
PIM2	PKM	Thr454	RAPIIAVtRNPQTAR	phosphorylation up-regulates quantity by stabilization	24142698	SIGNOR-267472
PIM2	PKM	Thr454	RAPIIAVtRNPQTAR	phosphorylation up-regulates quantity by stabilization	24142698	SIGNOR-260905
PIM2	CDC25A	–		phosphorylation down-regulates quantity by destabilization	22506047	SIGNOR-279750
PIM2	CDKN1A	Thr145	QGRKRRQtSMTDFYH	phosphorylation up-regulates quantity by stabilization	20307683	SIGNOR-164646
PIM2	PRKAA1	Ser467	LQLYQVDsRTYLLDF	phosphorylation down-regulates activity	31358902	SIGNOR-277471
PIM2	PSMD2	Ser361	ENNRFGGsGSQVDSA	phosphorylation up-regulates activity	31843888	SIGNOR-273896
PIM2	EIF4EBP1	–		phosphorylation up-regulates activity	19290049	SIGNOR-279091
PIM2	PFKFB3	Ser478	TKKPRINsFEEHVAS	phosphorylation up-regulates quantity by stabilization	33931981	SIGNOR-277554
PIM2	BAD	Ser118	GRELRRMsDEFVDSF	phosphorylation down-regulates	10837473	SIGNOR-78015
PIM2	BAD	Ser118	GRELRRMsDEFVDSF	phosphorylation down-regulates activity	16403219	SIGNOR-250395
PIM2	BAD	Ser75	EIRSRHSsYPAGTED	phosphorylation down-regulates activity	16403219	SIGNOR-249604
PIM2	BAD	Ser99	PFRGRSRsAPPNLWA	phosphorylation down-regulates activity	16403219	SIGNOR-250394
PIM2	PK	–		phosphorylation down-regulates activity	24142698	SIGNOR-268148
PIM2	PK	–		phosphorylation up-regulates quantity by stabilization	24142698	SIGNOR-268151
PIM2	PK	–		phosphorylation up-regulates quantity by stabilization	24142698	SIGNOR-270287

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
PIM2	phosphorylation up-regulates →	PKM PThr454	phosphorylation up-regulates →	PKM	24142698	SIGNOR-267472
PIM2	phosphorylation up-regulates →	PKM PThr454	phosphorylation up-regulates →	PKM	24142698	SIGNOR-260905
PIM2	phosphorylation up-regulates →	CDKN1A PThr145	phosphorylation up-regulates →	CDKN1A	20307683	SIGNOR-164646
PIM2	phosphorylation up-regulates →	PRKAA1 PSer467	phosphorylation down-regulates ⊣	PRKAA1	31358902	SIGNOR-277471
PIM2	phosphorylation up-regulates →	PSMD2 PSer361	phosphorylation up-regulates →	PSMD2	31843888	SIGNOR-273896
PIM2	phosphorylation up-regulates →	PFKFB3 PSer478	phosphorylation up-regulates →	PFKFB3	33931981	SIGNOR-277554
PIM2	phosphorylation up-regulates →	BAD PSer118	phosphorylation down-regulates ⊣	BAD	10837473	SIGNOR-78015
PIM2	phosphorylation up-regulates →	BAD PSer118	phosphorylation down-regulates ⊣	BAD	16403219	SIGNOR-250395
PIM2	phosphorylation up-regulates →	BAD PSer75	phosphorylation down-regulates ⊣	BAD	16403219	SIGNOR-249604
PIM2	phosphorylation up-regulates →	BAD PSer99	phosphorylation down-regulates ⊣	BAD	16403219	SIGNOR-250394

Regulator	Mechanism/Effect	Target	SIGNOR-ID
PIM2	phosphorylation → up-regulates activity	NFATC1	SIGNOR-276772
PIM2	phosphorylation → up-regulates quantity by stabilization	PKM	SIGNOR-267472
PIM2	phosphorylation → up-regulates quantity by stabilization	PKM	SIGNOR-260905
PIM2	phosphorylation down-regulates quantity by destabilization	CDC25A	SIGNOR-279750
PIM2	phosphorylation → up-regulates quantity by stabilization	CDKN1A	SIGNOR-164646
PIM2	phosphorylation → down-regulates activity	PRKAA1	SIGNOR-277471
PIM2	phosphorylation → up-regulates activity	PSMD2	SIGNOR-273896
PIM2	phosphorylation → up-regulates activity	EIF4EBP1	SIGNOR-279091
PIM2	phosphorylation → up-regulates quantity by stabilization	PFKFB3	SIGNOR-277554
PIM2	phosphorylation down-regulates	BAD	SIGNOR-78015
PIM2	phosphorylation → down-regulates activity	BAD	SIGNOR-250395
PIM2	phosphorylation → down-regulates activity	BAD	SIGNOR-249604
PIM2	phosphorylation → down-regulates activity	BAD	SIGNOR-250394
PIM2	phosphorylation → down-regulates activity	PK	SIGNOR-268148
PIM2	phosphorylation → up-regulates quantity by stabilization	PK	SIGNOR-268151
PIM2	phosphorylation → up-regulates quantity by stabilization	PK	SIGNOR-270287