| Name | EIF2AK4 |
| ID | Q9P2K8 |
| Role | kinase |
| Enzymatic Domains |
RWD 25-137 PROSITE-ProRule
Protein kinase 1 296-539 PROSITE-ProRule
Protein kinase 2 590-1001 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| EIF2AK4 | EIF2S1 | Ser52 | MILLSELsRRRIRSI | phosphorylation down-regulates activity | 32513922 | SIGNOR-246157 |
| EIF2AK4 | MARS1 | Ser662 | NRAGMFVsKFFGGYV | phosphorylation down-regulates | 22106287 | SIGNOR-177648 |
| EIF2AK4 | EIF2A | – | phosphorylation down-regulates activity | 19498172 | SIGNOR-280005 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| EIF2AK4 | phosphorylation up-regulates → | EIF2S1 PSer52 | phosphorylation down-regulates ⊣ | EIF2S1 | 32513922 | SIGNOR-246157 |
| EIF2AK4 | phosphorylation up-regulates → | MARS1 PSer662 | phosphorylation down-regulates ⊣ | MARS1 | 22106287 | SIGNOR-177648 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| EIF2AK4 | phosphorylation → down-regulates activity | EIF2S1 | SIGNOR-246157 |
| EIF2AK4 | phosphorylation down-regulates | MARS1 | SIGNOR-177648 |
| EIF2AK4 | phosphorylation → down-regulates activity | EIF2A | SIGNOR-280005 |