| Name | NLK |
| ID | Q9UBE8 |
| Role | kinase |
| Enzymatic Domains |
Protein kinase 138-427 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| NLK | MYB | – | phosphorylation down-regulates activity | 23935942 | SIGNOR-280049 | |
| NLK | TCF4 | – | phosphorylation down-regulates | 2861485 | SIGNOR-24147 | |
| NLK | STAT3 | Ser727 | NTIDLPMsPRTLDSL | phosphorylation up-regulates | 17563747 | SIGNOR-155828 |
| NLK | NOTCH1 | – | phosphorylation down-regulates | 20118921 | SIGNOR-163697 | |
| NLK | YAP1 | Ser128 | QHVRAHSsPASLQLG | phosphorylation up-regulates activity | 27979971 | SIGNOR-273909 |
| NLK | FOXO1 | Ser329 | STISGRLsPIMTEQD | phosphorylation down-regulates activity | 20061393 | SIGNOR-273907 |
| NLK | RPTOR | Ser863 | LTQSAPAsPTNKGVH | phosphorylation down-regulates activity | 26588989 | SIGNOR-273908 |
| NLK | CREBBP | – | phosphorylation up-regulates activity | 14720327 | SIGNOR-280048 | |
| NLK | TCF7L2 | Thr201 | PHHVHPLtPLITYSN | phosphorylation down-regulates | 12556497 | SIGNOR-97819 |
| NLK | TCF7L2 | Thr212 | TYSNEHFtPGNPPPH | phosphorylation down-regulates | 12556497 | SIGNOR-97873 |
| NLK | TCF7L2 | – | phosphorylation down-regulates quantity | 16714285 | SIGNOR-271597 | |
| NLK | LEF1 | Ser166 | TYSDEHFsPGSHPSH | phosphorylation down-regulates | 12556497 | SIGNOR-97808 |
| NLK | LEF1 | Thr155 | SHAVHPLtPLITYSD | phosphorylation down-regulates | 12556497 | SIGNOR-97812 |
| NLK | LEF1 | – | phosphorylation down-regulates quantity | 16714285 | SIGNOR-271596 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| NLK | phosphorylation up-regulates → | STAT3 PSer727 | phosphorylation up-regulates → | STAT3 | 17563747 | SIGNOR-155828 |
| NLK | phosphorylation up-regulates → | YAP1 PSer128 | phosphorylation up-regulates → | YAP1 | 27979971 | SIGNOR-273909 |
| NLK | phosphorylation up-regulates → | FOXO1 PSer329 | phosphorylation down-regulates ⊣ | FOXO1 | 20061393 | SIGNOR-273907 |
| NLK | phosphorylation up-regulates → | RPTOR PSer863 | phosphorylation down-regulates ⊣ | RPTOR | 26588989 | SIGNOR-273908 |
| NLK | phosphorylation up-regulates → | TCF7L2 PThr201 | phosphorylation down-regulates ⊣ | TCF7L2 | 12556497 | SIGNOR-97819 |
| NLK | phosphorylation up-regulates → | TCF7L2 PThr212 | phosphorylation down-regulates ⊣ | TCF7L2 | 12556497 | SIGNOR-97873 |
| NLK | phosphorylation up-regulates → | LEF1 PSer166 | phosphorylation down-regulates ⊣ | LEF1 | 12556497 | SIGNOR-97808 |
| NLK | phosphorylation up-regulates → | LEF1 PThr155 | phosphorylation down-regulates ⊣ | LEF1 | 12556497 | SIGNOR-97812 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| NLK | phosphorylation → down-regulates activity | MYB | SIGNOR-280049 |
| NLK | phosphorylation down-regulates | TCF4 | SIGNOR-24147 |
| NLK | phosphorylation → up-regulates | STAT3 | SIGNOR-155828 |
| NLK | phosphorylation down-regulates | NOTCH1 | SIGNOR-163697 |
| NLK | phosphorylation → up-regulates activity | YAP1 | SIGNOR-273909 |
| NLK | phosphorylation → down-regulates activity | FOXO1 | SIGNOR-273907 |
| NLK | phosphorylation → down-regulates activity | RPTOR | SIGNOR-273908 |
| NLK | phosphorylation → up-regulates activity | CREBBP | SIGNOR-280048 |
| NLK | phosphorylation down-regulates | TCF7L2 | SIGNOR-97819 |
| NLK | phosphorylation down-regulates | TCF7L2 | SIGNOR-97873 |
| NLK | phosphorylation → down-regulates quantity | TCF7L2 | SIGNOR-271597 |
| NLK | phosphorylation down-regulates | LEF1 | SIGNOR-97808 |
| NLK | phosphorylation down-regulates | LEF1 | SIGNOR-97812 |
| NLK | phosphorylation → down-regulates quantity | LEF1 | SIGNOR-271596 |