| Name | PPARGC1A |
| ID | Q9UBK2 |
| Role | substrate |
| Enzymatic Domains |
RRM 677-753 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKAA1 | PPARGC1A | Ser539 | SLFNVSPsCSSFNSP | phosphorylation up-regulates activity | 17609368 | SIGNOR-228654 |
| CLK2 | PPARGC1A | – | phosphorylation down-regulates activity | 20074525 | SIGNOR-278228 | |
| MAPK14 | PPARGC1A | Thr299 | AGLTPPTtPPHKANQ | phosphorylation up-regulates | 11741533 | SIGNOR-112774 |
| AMPK | PPARGC1A | Thr178 | NHNHRIRtNPAIVKT | phosphorylation up-regulates activity | 20640476 | SIGNOR-209936 |
| MAPK14 | PPARGC1A | Ser266 | SLPLTPEsPNDPKGS | phosphorylation up-regulates | 11741533 | SIGNOR-112766 |
| PRKAA1 | PPARGC1A | Thr178 | NHNHRIRtNPAIVKT | phosphorylation up-regulates activity | 17609368 | SIGNOR-156780 |
| AMPK | PPARGC1A | Thr178 | NHNHRIRtNPAIVKT | phosphorylation up-regulates | 17609368 | SIGNOR-216651 |
| AKT | PPARGC1A | Ser571 | RMRSRSRsFSRHRSC | phosphorylation down-regulates activity | 17554339 | SIGNOR-155532 |
| AMPK | PPARGC1A | Thr178 | NHNHRIRtNPAIVKT | phosphorylation up-regulates activity | 17609368 | SIGNOR-228642 |
| AMPK | PPARGC1A | Ser539 | SLFNVSPsCSSFNSP | phosphorylation up-regulates activity | 20640476 | SIGNOR-209940 |
| AKT1 | PPARGC1A | Ser571 | RMRSRSRsFSRHRSC | phosphorylation down-regulates activity | 17554339 | SIGNOR-252502 |
| AMPK | PPARGC1A | Ser539 | SLFNVSPsCSSFNSP | phosphorylation up-regulates activity | 17609368 | SIGNOR-228646 |
| AKT2 | PPARGC1A | Ser571 | RMRSRSRsFSRHRSC | phosphorylation down-regulates | 17554339 | SIGNOR-155536 |
| PRKDC | PPARGC1A | Ser636 | SRRPRYDsYEEYQHE | phosphorylation down-regulates quantity by destabilization | 36696363 | SIGNOR-277911 |
| MAPK14 | PPARGC1A | Thr263 | TTLSLPLtPESPNDP | phosphorylation up-regulates | 11741533 | SIGNOR-112770 |
| GSK3B | PPARGC1A | – | phosphorylation down-regulates quantity | 25118933 | SIGNOR-279723 | |
| AMPK | PPARGC1A | Ser539 | SLFNVSPsCSSFNSP | phosphorylation up-regulates | 17609368 | SIGNOR-216647 |
| AKT2 | PPARGC1A | Ser571 | RMRSRSRsFSRHRSC | phosphorylation down-regulates activity | 17554339 | SIGNOR-262626 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKAA1 | phosphorylation up-regulates → | PPARGC1A PSer539 | phosphorylation up-regulates → | PPARGC1A | 17609368 | SIGNOR-228654 |
| MAPK14 | phosphorylation up-regulates → | PPARGC1A PThr299 | phosphorylation up-regulates → | PPARGC1A | 11741533 | SIGNOR-112774 |
| AMPK | phosphorylation up-regulates → | PPARGC1A PThr178 | phosphorylation up-regulates → | PPARGC1A | 20640476 | SIGNOR-209936 |
| MAPK14 | phosphorylation up-regulates → | PPARGC1A PSer266 | phosphorylation up-regulates → | PPARGC1A | 11741533 | SIGNOR-112766 |
| PRKAA1 | phosphorylation up-regulates → | PPARGC1A PThr178 | phosphorylation up-regulates → | PPARGC1A | 17609368 | SIGNOR-156780 |
| AMPK | phosphorylation up-regulates → | PPARGC1A PThr178 | phosphorylation up-regulates → | PPARGC1A | 17609368 | SIGNOR-216651 |
| AKT | phosphorylation up-regulates → | PPARGC1A PSer571 | phosphorylation down-regulates ⊣ | PPARGC1A | 17554339 | SIGNOR-155532 |
| AMPK | phosphorylation up-regulates → | PPARGC1A PThr178 | phosphorylation up-regulates → | PPARGC1A | 17609368 | SIGNOR-228642 |
| AMPK | phosphorylation up-regulates → | PPARGC1A PSer539 | phosphorylation up-regulates → | PPARGC1A | 20640476 | SIGNOR-209940 |
| AKT1 | phosphorylation up-regulates → | PPARGC1A PSer571 | phosphorylation down-regulates ⊣ | PPARGC1A | 17554339 | SIGNOR-252502 |
| AMPK | phosphorylation up-regulates → | PPARGC1A PSer539 | phosphorylation up-regulates → | PPARGC1A | 17609368 | SIGNOR-228646 |
| AKT2 | phosphorylation up-regulates → | PPARGC1A PSer571 | phosphorylation down-regulates ⊣ | PPARGC1A | 17554339 | SIGNOR-155536 |
| PRKDC | phosphorylation up-regulates → | PPARGC1A PSer636 | phosphorylation down-regulates ⊣ | PPARGC1A | 36696363 | SIGNOR-277911 |
| MAPK14 | phosphorylation up-regulates → | PPARGC1A PThr263 | phosphorylation up-regulates → | PPARGC1A | 11741533 | SIGNOR-112770 |
| AMPK | phosphorylation up-regulates → | PPARGC1A PSer539 | phosphorylation up-regulates → | PPARGC1A | 17609368 | SIGNOR-216647 |
| AKT2 | phosphorylation up-regulates → | PPARGC1A PSer571 | phosphorylation down-regulates ⊣ | PPARGC1A | 17554339 | SIGNOR-262626 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKAA1 | phosphorylation → up-regulates activity | PPARGC1A | SIGNOR-228654 |
| CLK2 | phosphorylation → down-regulates activity | PPARGC1A | SIGNOR-278228 |
| MAPK14 | phosphorylation → up-regulates | PPARGC1A | SIGNOR-112774 |
| AMPK | phosphorylation → up-regulates activity | PPARGC1A | SIGNOR-209936 |
| MAPK14 | phosphorylation → up-regulates | PPARGC1A | SIGNOR-112766 |
| PRKAA1 | phosphorylation → up-regulates activity | PPARGC1A | SIGNOR-156780 |
| AMPK | phosphorylation → up-regulates | PPARGC1A | SIGNOR-216651 |
| AKT | phosphorylation → down-regulates activity | PPARGC1A | SIGNOR-155532 |
| AMPK | phosphorylation → up-regulates activity | PPARGC1A | SIGNOR-228642 |
| AMPK | phosphorylation → up-regulates activity | PPARGC1A | SIGNOR-209940 |
| AKT1 | phosphorylation → down-regulates activity | PPARGC1A | SIGNOR-252502 |
| AMPK | phosphorylation → up-regulates activity | PPARGC1A | SIGNOR-228646 |
| AKT2 | phosphorylation down-regulates | PPARGC1A | SIGNOR-155536 |
| PRKDC | phosphorylation down-regulates quantity by destabilization | PPARGC1A | SIGNOR-277911 |
| MAPK14 | phosphorylation → up-regulates | PPARGC1A | SIGNOR-112770 |
| GSK3B | phosphorylation → down-regulates quantity | PPARGC1A | SIGNOR-279723 |
| AMPK | phosphorylation → up-regulates | PPARGC1A | SIGNOR-216647 |
| AKT2 | phosphorylation → down-regulates activity | PPARGC1A | SIGNOR-262626 |