| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT2 | PPARGC1A | Ser571 | RMRSRSRsFSRHRSC | phosphorylation down-regulates | 17554339 | SIGNOR-155536 |
| AKT2 | PPARGC1A | Ser571 | RMRSRSRsFSRHRSC | phosphorylation down-regulates activity | 17554339 | SIGNOR-262626 |
| AKT | PPARGC1A | Ser571 | RMRSRSRsFSRHRSC | phosphorylation down-regulates activity | 17554339 | SIGNOR-155532 |
| AKT1 | PPARGC1A | Ser571 | RMRSRSRsFSRHRSC | phosphorylation down-regulates activity | 17554339 | SIGNOR-252502 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT2 | phosphorylation up-regulates → | PPARGC1A PSer571 | phosphorylation down-regulates ⊣ | PPARGC1A | 17554339 | SIGNOR-155536 |
| AKT2 | phosphorylation up-regulates → | PPARGC1A PSer571 | phosphorylation down-regulates ⊣ | PPARGC1A | 17554339 | SIGNOR-262626 |
| AKT | phosphorylation up-regulates → | PPARGC1A PSer571 | phosphorylation down-regulates ⊣ | PPARGC1A | 17554339 | SIGNOR-155532 |
| AKT1 | phosphorylation up-regulates → | PPARGC1A PSer571 | phosphorylation down-regulates ⊣ | PPARGC1A | 17554339 | SIGNOR-252502 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| AKT2 | phosphorylation![]() down-regulates | PPARGC1A | SIGNOR-155536 |
| AKT2 | phosphorylation → down-regulates activity | PPARGC1A | SIGNOR-262626 |
| AKT | phosphorylation → down-regulates activity | PPARGC1A | SIGNOR-155532 |
| AKT1 | phosphorylation → down-regulates activity | PPARGC1A | SIGNOR-252502 |