| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AMPK | PPARGC1A | Thr178 | NHNHRIRtNPAIVKT | phosphorylation up-regulates activity | 20640476 | SIGNOR-209936 |
| PRKAA1 | PPARGC1A | Thr178 | NHNHRIRtNPAIVKT | phosphorylation up-regulates activity | 17609368 | SIGNOR-156780 |
| AMPK | PPARGC1A | Thr178 | NHNHRIRtNPAIVKT | phosphorylation up-regulates | 17609368 | SIGNOR-216651 |
| AMPK | PPARGC1A | Thr178 | NHNHRIRtNPAIVKT | phosphorylation up-regulates activity | 17609368 | SIGNOR-228642 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AMPK | phosphorylation up-regulates → | PPARGC1A PThr178 | phosphorylation up-regulates → | PPARGC1A | 20640476 | SIGNOR-209936 |
| PRKAA1 | phosphorylation up-regulates → | PPARGC1A PThr178 | phosphorylation up-regulates → | PPARGC1A | 17609368 | SIGNOR-156780 |
| AMPK | phosphorylation up-regulates → | PPARGC1A PThr178 | phosphorylation up-regulates → | PPARGC1A | 17609368 | SIGNOR-216651 |
| AMPK | phosphorylation up-regulates → | PPARGC1A PThr178 | phosphorylation up-regulates → | PPARGC1A | 17609368 | SIGNOR-228642 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| AMPK | phosphorylation → up-regulates activity | PPARGC1A | SIGNOR-209936 |
| PRKAA1 | phosphorylation → up-regulates activity | PPARGC1A | SIGNOR-156780 |
| AMPK | phosphorylation → up-regulates | PPARGC1A | SIGNOR-216651 |
| AMPK | phosphorylation → up-regulates activity | PPARGC1A | SIGNOR-228642 |