Entity Details

Name	HDAC6
ID	Q9UBN7
Role	substrate
Enzymatic Domains
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Data Summary

PTM Format

SIGNOR Summary

Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
GSK3B	HDAC6	Ser22 View in OncoXplorer	RSRQNPQsPPQDSSV	phosphorylation up-regulates activity	20520769	SIGNOR-278941
MAPK3	HDAC6	Thr1031	ASSTDHQtPPTSPVQ	phosphorylation up-regulates	24089523	SIGNOR-202702
ERK1/2	HDAC6	Ser1035	DHQTPPTsPVQGTTP	phosphorylation up-regulates	24089523	SIGNOR-244545
ERK1/2	HDAC6	Thr1031	ASSTDHQtPPTSPVQ	phosphorylation up-regulates	24089523	SIGNOR-244549
MAPK3	HDAC6	Ser1035	DHQTPPTsPVQGTTP	phosphorylation up-regulates	24089523	SIGNOR-202698
EGFR	HDAC6	Tyr570	SSNFDSIyICPSTFA	phosphorylation down-regulates	20029029	SIGNOR-162431

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
GSK3B	phosphorylation up-regulates →	HDAC6 PSer22	phosphorylation up-regulates →	HDAC6	20520769	SIGNOR-278941
MAPK3	phosphorylation up-regulates →	HDAC6 PThr1031	phosphorylation up-regulates →	HDAC6	24089523	SIGNOR-202702
ERK1/2	phosphorylation up-regulates →	HDAC6 PSer1035	phosphorylation up-regulates →	HDAC6	24089523	SIGNOR-244545
ERK1/2	phosphorylation up-regulates →	HDAC6 PThr1031	phosphorylation up-regulates →	HDAC6	24089523	SIGNOR-244549
MAPK3	phosphorylation up-regulates →	HDAC6 PSer1035	phosphorylation up-regulates →	HDAC6	24089523	SIGNOR-202698
EGFR	phosphorylation up-regulates →	HDAC6 PTyr570	phosphorylation down-regulates ⊣	HDAC6	20029029	SIGNOR-162431

Regulator	Mechanism/Effect	Target	SIGNOR-ID
GSK3B	phosphorylation → up-regulates activity	HDAC6	SIGNOR-278941
MAPK3	phosphorylation → up-regulates	HDAC6	SIGNOR-202702
ERK1/2	phosphorylation → up-regulates	HDAC6	SIGNOR-244545
ERK1/2	phosphorylation → up-regulates	HDAC6	SIGNOR-244549
MAPK3	phosphorylation → up-regulates	HDAC6	SIGNOR-202698
EGFR	phosphorylation down-regulates	HDAC6	SIGNOR-162431