| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| RPS6KA1 | METTL1 | Ser27 | YYRQRAHsNPMADHT | phosphorylation down-regulates | 15861136 | SIGNOR-135948 |
| AKT | METTL1 | Ser27 | YYRQRAHsNPMADHT | phosphorylation down-regulates | 3627513 | SIGNOR-244307 |
| AKT1 | METTL1 | Ser27 | YYRQRAHsNPMADHT | phosphorylation down-regulates | 3627513 | SIGNOR-24994 |
| RPS6K | METTL1 | Ser27 | YYRQRAHsNPMADHT | phosphorylation down-regulates | 15861136 | SIGNOR-252800 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| RPS6KA1 | phosphorylation up-regulates → | METTL1 PSer27 | phosphorylation down-regulates ⊣ | METTL1 | 15861136 | SIGNOR-135948 |
| AKT | phosphorylation up-regulates → | METTL1 PSer27 | phosphorylation down-regulates ⊣ | METTL1 | 3627513 | SIGNOR-244307 |
| AKT1 | phosphorylation up-regulates → | METTL1 PSer27 | phosphorylation down-regulates ⊣ | METTL1 | 3627513 | SIGNOR-24994 |
| RPS6K | phosphorylation up-regulates → | METTL1 PSer27 | phosphorylation down-regulates ⊣ | METTL1 | 15861136 | SIGNOR-252800 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| RPS6KA1 | phosphorylation down-regulates | METTL1 | SIGNOR-135948 |
| AKT | phosphorylation down-regulates | METTL1 | SIGNOR-244307 |
| AKT1 | phosphorylation down-regulates | METTL1 | SIGNOR-24994 |
| RPS6K | phosphorylation down-regulates | METTL1 | SIGNOR-252800 |
