| Name | RPS6KB2 |
| ID | Q9UBS0 |
| Role | kinase |
| Enzymatic Domains |
Protein kinase 67-328 PROSITE-ProRule
AGC-kinase C-terminal 329-399 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| RPS6KB2 | HNRNPA1 | Ser6 | sPKEPEQL | phosphorylation up-regulates activity | 25324306 | SIGNOR-279569 |
| RPS6KB2 | MXD1 | Ser145 | IERIRMDsIGSTVSS | phosphorylation down-regulates | 18451027 | SIGNOR-178594 |
| RPS6KB2 | TARBP2 | Ser283 | ILSLRSCsLGSLGAL | phosphorylation up-regulates activity | 27407113 | SIGNOR-274066 |
| RPS6KB2 | TARBP2 | Ser286 | LRSCSLGsLGALGPA | phosphorylation up-regulates activity | 27407113 | SIGNOR-274069 |
| RPS6KB2 | PDCD4 | – | phosphorylation down-regulates | 18296647 | SIGNOR-160992 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| RPS6KB2 | phosphorylation up-regulates → | HNRNPA1 PSer6 | phosphorylation up-regulates → | HNRNPA1 | 25324306 | SIGNOR-279569 |
| RPS6KB2 | phosphorylation up-regulates → | MXD1 PSer145 | phosphorylation down-regulates ⊣ | MXD1 | 18451027 | SIGNOR-178594 |
| RPS6KB2 | phosphorylation up-regulates → | TARBP2 PSer283 | phosphorylation up-regulates → | TARBP2 | 27407113 | SIGNOR-274066 |
| RPS6KB2 | phosphorylation up-regulates → | TARBP2 PSer286 | phosphorylation up-regulates → | TARBP2 | 27407113 | SIGNOR-274069 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| RPS6KB2 | phosphorylation → up-regulates activity | HNRNPA1 | SIGNOR-279569 |
| RPS6KB2 | phosphorylation down-regulates | MXD1 | SIGNOR-178594 |
| RPS6KB2 | phosphorylation → up-regulates activity | TARBP2 | SIGNOR-274066 |
| RPS6KB2 | phosphorylation → up-regulates activity | TARBP2 | SIGNOR-274069 |
| RPS6KB2 | phosphorylation down-regulates | PDCD4 | SIGNOR-160992 |