| Name | RPS6KB2 |
| ID | Q9UBS0 |
| Role | substrate |
| Enzymatic Domains |
Protein kinase 67-328 PROSITE-ProRule
AGC-kinase C-terminal 329-399 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MTOR | RPS6KB2 | – | phosphorylation up-regulates | 17510057 | SIGNOR-154821 | |
| MTOR | RPS6KB2 | – | phosphorylation up-regulates | 23486913 | SIGNOR-201541 | |
| PDPK1 | RPS6KB2 | Thr228 | HEGAVTHtFCGTIEY | phosphorylation up-regulates | 9445476 | SIGNOR-55371 |
| MTOR | RPS6KB2 | Thr228 | HEGAVTHtFCGTIEY | phosphorylation up-regulates activity | 11733037 | SIGNOR-250294 |
| PRKCD | RPS6KB2 | Ser473 | PPSGTKKsKRGRGRP | phosphorylation unknown | 12529391 | SIGNOR-97287 |
| PDPK1 | RPS6KB2 | Thr228 | HEGAVTHtFCGTIEY | phosphorylation up-regulates | 15209375 | SIGNOR-126076 |
| PDPK1 | RPS6KB2 | Thr388 | NQAFLGFtYVAPSVL | phosphorylation up-regulates activity | 11733037 | SIGNOR-250272 |
| MTOR | RPS6KB2 | Thr388 | NQAFLGFtYVAPSVL | phosphorylation up-regulates activity | 11733037 | SIGNOR-250295 |
| MTOR | RPS6KB2 | Ser370 | TRQTPVDsPDDTALS | phosphorylation up-regulates activity | 11733037 | SIGNOR-250293 |
| SRC | RPS6KB2 | Tyr45 | GLEPVGHyEEVELTE | phosphorylation unknown | 16640565 | SIGNOR-146292 |
| PDPK1 | RPS6KB2 | Ser370 | TRQTPVDsPDDTALS | phosphorylation up-regulates activity | 11733037 | SIGNOR-250371 |
| PRKCE | RPS6KB2 | Ser473 | PPSGTKKsKRGRGRP | phosphorylation unknown | 12529391 | SIGNOR-97291 |
| PDPK1 | RPS6KB2 | Thr228 | HEGAVTHtFCGTIEY | phosphorylation up-regulates activity | 11733037 | SIGNOR-250273 |
| PRKCG | RPS6KB2 | Ser473 | PPSGTKKsKRGRGRP | phosphorylation unknown | 12529391 | SIGNOR-97295 |
| PRKCA | RPS6KB2 | Ser473 | PPSGTKKsKRGRGRP | phosphorylation unknown | 12529391 | SIGNOR-97279 |
| mTORC1 | RPS6KB2 | – | phosphorylation up-regulates | 17510057 | SIGNOR-217074 | |
| PRKCB | RPS6KB2 | Ser473 | PPSGTKKsKRGRGRP | phosphorylation unknown | 12529391 | SIGNOR-97283 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PDPK1 | phosphorylation up-regulates → | RPS6KB2 PThr228 | phosphorylation up-regulates → | RPS6KB2 | 9445476 | SIGNOR-55371 |
| MTOR | phosphorylation up-regulates → | RPS6KB2 PThr228 | phosphorylation up-regulates → | RPS6KB2 | 11733037 | SIGNOR-250294 |
| PRKCD | phosphorylation up-regulates → | RPS6KB2 PSer473 | phosphorylation down-regulates ⊣ | RPS6KB2 | 12529391 | SIGNOR-97287 |
| PDPK1 | phosphorylation up-regulates → | RPS6KB2 PThr228 | phosphorylation up-regulates → | RPS6KB2 | 15209375 | SIGNOR-126076 |
| PDPK1 | phosphorylation up-regulates → | RPS6KB2 PThr388 | phosphorylation up-regulates → | RPS6KB2 | 11733037 | SIGNOR-250272 |
| MTOR | phosphorylation up-regulates → | RPS6KB2 PThr388 | phosphorylation up-regulates → | RPS6KB2 | 11733037 | SIGNOR-250295 |
| MTOR | phosphorylation up-regulates → | RPS6KB2 PSer370 | phosphorylation up-regulates → | RPS6KB2 | 11733037 | SIGNOR-250293 |
| SRC | phosphorylation up-regulates → | RPS6KB2 PTyr45 | phosphorylation down-regulates ⊣ | RPS6KB2 | 16640565 | SIGNOR-146292 |
| PDPK1 | phosphorylation up-regulates → | RPS6KB2 PSer370 | phosphorylation up-regulates → | RPS6KB2 | 11733037 | SIGNOR-250371 |
| PRKCE | phosphorylation up-regulates → | RPS6KB2 PSer473 | phosphorylation down-regulates ⊣ | RPS6KB2 | 12529391 | SIGNOR-97291 |
| PDPK1 | phosphorylation up-regulates → | RPS6KB2 PThr228 | phosphorylation up-regulates → | RPS6KB2 | 11733037 | SIGNOR-250273 |
| PRKCG | phosphorylation up-regulates → | RPS6KB2 PSer473 | phosphorylation down-regulates ⊣ | RPS6KB2 | 12529391 | SIGNOR-97295 |
| PRKCA | phosphorylation up-regulates → | RPS6KB2 PSer473 | phosphorylation down-regulates ⊣ | RPS6KB2 | 12529391 | SIGNOR-97279 |
| PRKCB | phosphorylation up-regulates → | RPS6KB2 PSer473 | phosphorylation down-regulates ⊣ | RPS6KB2 | 12529391 | SIGNOR-97283 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MTOR | phosphorylation → up-regulates | RPS6KB2 | SIGNOR-154821 |
| MTOR | phosphorylation → up-regulates | RPS6KB2 | SIGNOR-201541 |
| PDPK1 | phosphorylation → up-regulates | RPS6KB2 | SIGNOR-55371 |
| MTOR | phosphorylation → up-regulates activity | RPS6KB2 | SIGNOR-250294 |
| PRKCD | phosphorylation → unknown | RPS6KB2 | SIGNOR-97287 |
| PDPK1 | phosphorylation → up-regulates | RPS6KB2 | SIGNOR-126076 |
| PDPK1 | phosphorylation → up-regulates activity | RPS6KB2 | SIGNOR-250272 |
| MTOR | phosphorylation → up-regulates activity | RPS6KB2 | SIGNOR-250295 |
| MTOR | phosphorylation → up-regulates activity | RPS6KB2 | SIGNOR-250293 |
| SRC | phosphorylation → unknown | RPS6KB2 | SIGNOR-146292 |
| PDPK1 | phosphorylation → up-regulates activity | RPS6KB2 | SIGNOR-250371 |
| PRKCE | phosphorylation → unknown | RPS6KB2 | SIGNOR-97291 |
| PDPK1 | phosphorylation → up-regulates activity | RPS6KB2 | SIGNOR-250273 |
| PRKCG | phosphorylation → unknown | RPS6KB2 | SIGNOR-97295 |
| PRKCA | phosphorylation → unknown | RPS6KB2 | SIGNOR-97279 |
| mTORC1 | phosphorylation → up-regulates | RPS6KB2 | SIGNOR-217074 |
| PRKCB | phosphorylation → unknown | RPS6KB2 | SIGNOR-97283 |