Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
ATR	DBF4	Thr449	DDIRQNFtQLPLHKN	phosphorylation down-regulates	22123827	SIGNOR-177813
ATM	DBF4	Thr449	DDIRQNFtQLPLHKN	phosphorylation down-regulates	22123827	SIGNOR-177801
ATR	DBF4	Ser502	FSTDNSGsQPKQKSD	phosphorylation down-regulates	22123827	SIGNOR-177805
ATR	DBF4	Ser539	GLITINSsQEHLTVQ	phosphorylation down-regulates	22123827	SIGNOR-177809
ATM	DBF4	Ser539	GLITINSsQEHLTVQ	phosphorylation down-regulates	22123827	SIGNOR-177797
ATM	DBF4	Ser502	FSTDNSGsQPKQKSD	phosphorylation down-regulates	22123827	SIGNOR-177793

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
ATR	phosphorylation up-regulates →	DBF4 PThr449	phosphorylation down-regulates ⊣	DBF4	22123827	SIGNOR-177813
ATM	phosphorylation up-regulates →	DBF4 PThr449	phosphorylation down-regulates ⊣	DBF4	22123827	SIGNOR-177801
ATR	phosphorylation up-regulates →	DBF4 PSer502	phosphorylation down-regulates ⊣	DBF4	22123827	SIGNOR-177805
ATR	phosphorylation up-regulates →	DBF4 PSer539	phosphorylation down-regulates ⊣	DBF4	22123827	SIGNOR-177809
ATM	phosphorylation up-regulates →	DBF4 PSer539	phosphorylation down-regulates ⊣	DBF4	22123827	SIGNOR-177797
ATM	phosphorylation up-regulates →	DBF4 PSer502	phosphorylation down-regulates ⊣	DBF4	22123827	SIGNOR-177793

Regulator	Mechanism/Effect	Target	SIGNOR-ID
ATR	phosphorylation down-regulates	DBF4	SIGNOR-177813
ATM	phosphorylation down-regulates	DBF4	SIGNOR-177801
ATR	phosphorylation down-regulates	DBF4	SIGNOR-177805
ATR	phosphorylation down-regulates	DBF4	SIGNOR-177809
ATM	phosphorylation down-regulates	DBF4	SIGNOR-177797
ATM	phosphorylation down-regulates	DBF4	SIGNOR-177793