| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| HIPK1 | DAXX | Ser668 | KKICTLPsPPSPLAS | phosphorylation down-regulates activity | 12529400 | SIGNOR-260842 |
| ATM | DAXX | Ser564 | LEEESPVsQLFELEI | phosphorylation down-regulates | 23405218 | SIGNOR-200889 |
| CSNK2A1 | DAXX | Ser739 | EIIVLSDsD | phosphorylation up-regulates | 21474068 | SIGNOR-173109 |
| CSNK2A1 | DAXX | Ser737 | PEEIIVLsDSD | phosphorylation up-regulates | 21474068 | SIGNOR-173105 |
| MAP3K5 | DAXX | Ser184 | QSPRTRGsRRQIQRL | phosphorylation up-regulates | 19789335 | SIGNOR-188325 |
| MAP3K5 | DAXX | Ser184 | QSPRTRGsRRQIQRL | phosphorylation up-regulates quantity by stabilization | 19789335 | SIGNOR-109684 |
| MAP3K5 | DAXX | Ser176 | TNAENTAsQSPRTRG | phosphorylation up-regulates quantity by stabilization | 19789335 | SIGNOR-109680 |
| MAP3K5 | DAXX | Ser176 | TNAENTAsQSPRTRG | phosphorylation up-regulates | 19789335 | SIGNOR-188321 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| HIPK1 | phosphorylation up-regulates → | DAXX PSer668 | phosphorylation down-regulates ⊣ | DAXX | 12529400 | SIGNOR-260842 |
| ATM | phosphorylation up-regulates → | DAXX PSer564 | phosphorylation down-regulates ⊣ | DAXX | 23405218 | SIGNOR-200889 |
| CSNK2A1 | phosphorylation up-regulates → | DAXX PSer739 | phosphorylation up-regulates → | DAXX | 21474068 | SIGNOR-173109 |
| CSNK2A1 | phosphorylation up-regulates → | DAXX PSer737 | phosphorylation up-regulates → | DAXX | 21474068 | SIGNOR-173105 |
| MAP3K5 | phosphorylation up-regulates → | DAXX PSer184 | phosphorylation up-regulates → | DAXX | 19789335 | SIGNOR-188325 |
| MAP3K5 | phosphorylation up-regulates → | DAXX PSer184 | phosphorylation up-regulates → | DAXX | 19789335 | SIGNOR-109684 |
| MAP3K5 | phosphorylation up-regulates → | DAXX PSer176 | phosphorylation up-regulates → | DAXX | 19789335 | SIGNOR-109680 |
| MAP3K5 | phosphorylation up-regulates → | DAXX PSer176 | phosphorylation up-regulates → | DAXX | 19789335 | SIGNOR-188321 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| HIPK1 | phosphorylation → down-regulates activity | DAXX | SIGNOR-260842 |
| ATM | phosphorylation down-regulates | DAXX | SIGNOR-200889 |
| CSNK2A1 | phosphorylation → up-regulates | DAXX | SIGNOR-173109 |
| CSNK2A1 | phosphorylation → up-regulates | DAXX | SIGNOR-173105 |
| MAP3K5 | phosphorylation → up-regulates | DAXX | SIGNOR-188325 |
| MAP3K5 | phosphorylation → up-regulates quantity by stabilization | DAXX | SIGNOR-109684 |
| MAP3K5 | phosphorylation → up-regulates quantity by stabilization | DAXX | SIGNOR-109680 |
| MAP3K5 | phosphorylation → up-regulates | DAXX | SIGNOR-188321 |
