| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| WNK4 | STK39 | Thr231 | TRNKVRKtFVGTPCW | phosphorylation up-regulates activity | 16990453 | SIGNOR-264640 |
| WNK1 | STK39 | Thr231 | TRNKVRKtFVGTPCW | phosphorylation up-regulates | 17190791 | SIGNOR-151671 |
| WNK1 | STK39 | Thr231 | TRNKVRKtFVGTPCW | phosphorylation up-regulates | 16083423 | SIGNOR-160846 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| WNK4 | phosphorylation up-regulates → | STK39 PThr231 | phosphorylation up-regulates → | STK39 | 16990453 | SIGNOR-264640 |
| WNK1 | phosphorylation up-regulates → | STK39 PThr231 | phosphorylation up-regulates → | STK39 | 17190791 | SIGNOR-151671 |
| WNK1 | phosphorylation up-regulates → | STK39 PThr231 | phosphorylation up-regulates → | STK39 | 16083423 | SIGNOR-160846 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| WNK4 | phosphorylation → up-regulates activity | STK39 | SIGNOR-264640 |
| WNK1 | phosphorylation → up-regulates | STK39 | SIGNOR-151671 |
| WNK1 | phosphorylation → up-regulates | STK39 | SIGNOR-160846 |
