| Name | TBK1 |
| ID | Q9UHD2 |
| Role | kinase |
| Enzymatic Domains |
Protein kinase 9-310 PROSITE-ProRule
Ubiquitin-like 309-385 |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| TBK1 | TNIP1 | Ser123 | PPSSGTSsEFEVVTP | phosphorylation down-regulates quantity by destabilization | 36574265 | SIGNOR-275734 |
| TBK1 | PBXIP1 | Ser147 | REEGRCSsSDDDTDV | phosphorylation down-regulates quantity by destabilization | 24488098 | SIGNOR-273643 |
| TBK1 | REL/RELA | – | phosphorylation up-regulates | 16888014 | SIGNOR-217667 | |
| TBK1 | IKBKB | – | phosphorylation up-regulates activity | 30791439 | SIGNOR-280017 | |
| TBK1 | CALCOCO2 | – | phosphorylation up-regulates activity | 32034138 | SIGNOR-280151 | |
| TBK1 | SIKE1 | – | phosphorylation down-regulates quantity | 23649622 | SIGNOR-280152 | |
| TBK1 | TNIP1 | – | phosphorylation down-regulates quantity by destabilization | 36574265 | SIGNOR-280153 | |
| TBK1 | IRF3 | – | phosphorylation up-regulates activity | 14679297 | SIGNOR-120355 | |
| TBK1 | IRF5 | Ser158 | QRMLPSLsLTEDVKW | phosphorylation up-regulates | 22412986 | SIGNOR-196528 |
| TBK1 | METTL3 | – | phosphorylation up-regulates activity | 35172162 | SIGNOR-279299 | |
| TBK1 | DDAH2 | Thr211 | DHPYASLtLPDDAAA | phosphorylation down-regulates activity | 33850055 | SIGNOR-275647 |
| TBK1 | PRPS2 | Thr228 | DMADTCGtICHAADK | phosphorylation up-regulates activity | 34343500 | SIGNOR-277317 |
| TBK1 | ELF4 | – | phosphorylation up-regulates activity | 24185615 | SIGNOR-279130 | |
| TBK1 | NFKBIA | Ser36 | RHDSGLDsMKDEEYE | phosphorylation down-regulates quantity by destabilization | 11815618 | SIGNOR-246643 |
| TBK1 | NfKb-p65/p50 | – | phosphorylation up-regulates activity | 15489227 | SIGNOR-260157 | |
| TBK1 | IRF3 | Ser402 | ISNSHPLsLTSDQYK | phosphorylation up-regulates activity | 18440553 | SIGNOR-178407 |
| TBK1 | AKT | Ser473 | RPHFPQFsYSASGTA | phosphorylation up-regulates | 21329883 | SIGNOR-172132 |
| TBK1 | IRF3 | Ser398 | VDLHISNsHPLSLTS | phosphorylation up-regulates activity | 18440553 | SIGNOR-178403 |
| TBK1 | MAP3K14 | – | phosphorylation down-regulates quantity by destabilization | 23023393 | SIGNOR-279767 | |
| TBK1 | OPTN | Ser177 | SSGSSEDsFVEIRMA | phosphorylation up-regulates activity | 26365381 | SIGNOR-278169 |
| TBK1 | RIPK1 | Thr189 | TAKKNGGtLYYMAPE | phosphorylation down-regulates activity | 30146158 | SIGNOR-279388 |
| TBK1 | VPS37C | – | phosphorylation down-regulates activity | 21270402 | SIGNOR-279768 | |
| TBK1 | STAT6 | Ser407 | PIQLQALsLPLVVIV | phosphorylation up-regulates | 22000020 | SIGNOR-176771 |
| TBK1 | IRF3 | Ser386 | ARVGGASsLENTVDL | phosphorylation up-regulates activity | 18440553 | SIGNOR-178395 |
| TBK1 | AKT1 | Ser473 | RPHFPQFsYSASGTA | phosphorylation up-regulates | 21329883 | SIGNOR-252608 |
| TBK1 | CDH1 | – | phosphorylation down-regulates activity | 33310066 | SIGNOR-278996 | |
| TBK1 | DDX3X | – | phosphorylation up-regulates activity | 18583960 | SIGNOR-278997 | |
| TBK1 | OPTN | Ser513 | FEDGGRQsLMEMQSR | phosphorylation up-regulates activity | 26365381 | SIGNOR-278171 |
| TBK1 | HDAC3 | – | phosphorylation up-regulates activity | 32772249 | SIGNOR-279662 | |
| TBK1 | SIKE1 | Ser187 | LRELLSIsSESLQAR | phosphorylation up-regulates quantity | 23649622 | SIGNOR-273814 |
| TBK1 | IRF3 | Thr404 | NSHPLSLtSDQYKAY | phosphorylation up-regulates activity | 18440553 | SIGNOR-178420 |
| TBK1 | TNIP1 | Ser122 | KPPSSGTsSEFEVVT | phosphorylation down-regulates quantity by destabilization | 36574265 | SIGNOR-275733 |
| TBK1 | SLC6A4 | Ser13 | LNSQKQLsACEDGED | phosphorylation up-regulates activity | 32757223 | SIGNOR-278384 |
| TBK1 | IRF5 | Ser293 | VELFGPIsLEQVRFP | phosphorylation up-regulates | 22412986 | SIGNOR-196532 |
| TBK1 | IRF3 | Ser385 | MARVGGAsSLENTVD | phosphorylation up-regulates activity | 18440553 | SIGNOR-178391 |
| TBK1 | STING1 | Ser358 | VPSTSTMsQEPELLI | phosphorylation up-regulates activity | 18818105 | SIGNOR-263136 |
| TBK1 | HTT | Ser13 | KLMKAFEsLKSFQQQ | phosphorylation up-regulates activity | 32757223 | SIGNOR-270350 |
| TBK1 | IRF7 | Ser479 | SLDSSSLsLCLSSAN | phosphorylation up-regulates activity | 22787218 | SIGNOR-278216 |
| TBK1 | MTOR | Ser2159 | RIQSIAPsLQVITSK | phosphorylation up-regulates activity | 32854217 | SIGNOR-278237 |
| TBK1 | REL | – | phosphorylation up-regulates | 16888014 | SIGNOR-148623 | |
| TBK1 | PRPS1 | Thr228 | DMADTCGtICHAADK | phosphorylation up-regulates activity | 34343500 | SIGNOR-277316 |
| TBK1 | RELA | Ser536 | SGDEDFSsIADMDFS | phosphorylation up-regulates | 15489227 | SIGNOR-129951 |
| TBK1 | CDC20 | – | phosphorylation down-regulates activity | 33310066 | SIGNOR-279766 | |
| TBK1 | SIKE1 | Ser185 | KELRELLsISSESLQ | phosphorylation up-regulates quantity | 23649622 | SIGNOR-273813 |
| TBK1 | DDAH2 | Thr203 | VRAMAVLtDHPYASL | phosphorylation down-regulates activity | 33850055 | SIGNOR-275645 |
| TBK1 | IRF3 | Ser405 | SHPLSLTsDQYKAYL | phosphorylation up-regulates activity | 18440553 | SIGNOR-178411 |
| TBK1 | DDAH2 | Ser253 | QEALQKLsDVTLVPV | phosphorylation down-regulates activity | 33850055 | SIGNOR-275646 |
| TBK1 | OPTN | Ser473 | AQMEVYCsDFHAERA | phosphorylation up-regulates activity | 26365381 | SIGNOR-278170 |
| TBK1 | SQSTM1 | Ser403 | ESLSQMLsMGFSDEG | phosphorylation up-regulates | 22921120 | SIGNOR-191944 |
| TBK1 | DDAH2 | Ser245 | GGGDLPNsQEALQKL | phosphorylation down-regulates activity | 33850055 | SIGNOR-275648 |
| TBK1 | STAT6 | Tyr641 | MGKDGRGyVPATIKM | phosphorylation up-regulates | 22000020 | SIGNOR-176775 |
| TBK1 | IRF3 | Ser396 | NTVDLHIsNSHPLSL | phosphorylation up-regulates activity | 18440553 | SIGNOR-178399 |
| TBK1 | SIKE1 | Ser133 | PVLKAHQsHSAEIES | phosphorylation up-regulates quantity | 23649622 | SIGNOR-273815 |
| TBK1 | SIKE1 | Ser188 | RELLSISsESLQARK | phosphorylation up-regulates quantity | 23649622 | SIGNOR-273816 |
| TBK1 | STX17 | Ser202 | SQQEKIDsIADHVNS | phosphorylation up-regulates activity | 30827897 | SIGNOR-273812 |
| TBK1 | PBXIP1 | Ser147 | REEGRCSsSDDDTDV | phosphorylation down-regulates quantity by destabilization | 24488098 | SIGNOR-273811 |
| TBK1 | SIKE1 | Ser190 | LLSISSEsLQARKEN | phosphorylation up-regulates quantity | 23649622 | SIGNOR-273817 |
| TBK1 | SIKE1 | Ser198 | LQARKENsMDTASQA | phosphorylation up-regulates quantity | 23649622 | SIGNOR-273818 |
| TBK1 | IRF3 | – | phosphorylation up-regulates activity | 24622840 | SIGNOR-260154 | |
| TBK1 | NUMA1 | – | phosphorylation up-regulates activity | 26656453 | SIGNOR-278432 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| TBK1 | phosphorylation up-regulates → | TNIP1 PSer123 | phosphorylation down-regulates ⊣ | TNIP1 | 36574265 | SIGNOR-275734 |
| TBK1 | phosphorylation up-regulates → | PBXIP1 PSer147 | phosphorylation down-regulates ⊣ | PBXIP1 | 24488098 | SIGNOR-273643 |
| TBK1 | phosphorylation up-regulates → | IRF5 PSer158 | phosphorylation up-regulates → | IRF5 | 22412986 | SIGNOR-196528 |
| TBK1 | phosphorylation up-regulates → | DDAH2 PThr211 | phosphorylation down-regulates ⊣ | DDAH2 | 33850055 | SIGNOR-275647 |
| TBK1 | phosphorylation up-regulates → | PRPS2 PThr228 | phosphorylation up-regulates → | PRPS2 | 34343500 | SIGNOR-277317 |
| TBK1 | phosphorylation up-regulates → | NFKBIA PSer36 | phosphorylation down-regulates ⊣ | NFKBIA | 11815618 | SIGNOR-246643 |
| TBK1 | phosphorylation up-regulates → | IRF3 PSer402 | phosphorylation up-regulates → | IRF3 | 18440553 | SIGNOR-178407 |
| TBK1 | phosphorylation up-regulates → | AKT PSer473 | phosphorylation up-regulates → | AKT | 21329883 | SIGNOR-172132 |
| TBK1 | phosphorylation up-regulates → | IRF3 PSer398 | phosphorylation up-regulates → | IRF3 | 18440553 | SIGNOR-178403 |
| TBK1 | phosphorylation up-regulates → | OPTN PSer177 | phosphorylation up-regulates → | OPTN | 26365381 | SIGNOR-278169 |
| TBK1 | phosphorylation up-regulates → | RIPK1 PThr189 | phosphorylation down-regulates ⊣ | RIPK1 | 30146158 | SIGNOR-279388 |
| TBK1 | phosphorylation up-regulates → | STAT6 PSer407 | phosphorylation up-regulates → | STAT6 | 22000020 | SIGNOR-176771 |
| TBK1 | phosphorylation up-regulates → | IRF3 PSer386 | phosphorylation up-regulates → | IRF3 | 18440553 | SIGNOR-178395 |
| TBK1 | phosphorylation up-regulates → | AKT1 PSer473 | phosphorylation up-regulates → | AKT1 | 21329883 | SIGNOR-252608 |
| TBK1 | phosphorylation up-regulates → | OPTN PSer513 | phosphorylation up-regulates → | OPTN | 26365381 | SIGNOR-278171 |
| TBK1 | phosphorylation up-regulates → | SIKE1 PSer187 | phosphorylation up-regulates → | SIKE1 | 23649622 | SIGNOR-273814 |
| TBK1 | phosphorylation up-regulates → | IRF3 PThr404 | phosphorylation up-regulates → | IRF3 | 18440553 | SIGNOR-178420 |
| TBK1 | phosphorylation up-regulates → | TNIP1 PSer122 | phosphorylation down-regulates ⊣ | TNIP1 | 36574265 | SIGNOR-275733 |
| TBK1 | phosphorylation up-regulates → | SLC6A4 PSer13 | phosphorylation up-regulates → | SLC6A4 | 32757223 | SIGNOR-278384 |
| TBK1 | phosphorylation up-regulates → | IRF5 PSer293 | phosphorylation up-regulates → | IRF5 | 22412986 | SIGNOR-196532 |
| TBK1 | phosphorylation up-regulates → | IRF3 PSer385 | phosphorylation up-regulates → | IRF3 | 18440553 | SIGNOR-178391 |
| TBK1 | phosphorylation up-regulates → | STING1 PSer358 | phosphorylation up-regulates → | STING1 | 18818105 | SIGNOR-263136 |
| TBK1 | phosphorylation up-regulates → | HTT PSer13 | phosphorylation up-regulates → | HTT | 32757223 | SIGNOR-270350 |
| TBK1 | phosphorylation up-regulates → | IRF7 PSer479 | phosphorylation up-regulates → | IRF7 | 22787218 | SIGNOR-278216 |
| TBK1 | phosphorylation up-regulates → | MTOR PSer2159 | phosphorylation up-regulates → | MTOR | 32854217 | SIGNOR-278237 |
| TBK1 | phosphorylation up-regulates → | PRPS1 PThr228 | phosphorylation up-regulates → | PRPS1 | 34343500 | SIGNOR-277316 |
| TBK1 | phosphorylation up-regulates → | RELA PSer536 | phosphorylation up-regulates → | RELA | 15489227 | SIGNOR-129951 |
| TBK1 | phosphorylation up-regulates → | SIKE1 PSer185 | phosphorylation up-regulates → | SIKE1 | 23649622 | SIGNOR-273813 |
| TBK1 | phosphorylation up-regulates → | DDAH2 PThr203 | phosphorylation down-regulates ⊣ | DDAH2 | 33850055 | SIGNOR-275645 |
| TBK1 | phosphorylation up-regulates → | IRF3 PSer405 | phosphorylation up-regulates → | IRF3 | 18440553 | SIGNOR-178411 |
| TBK1 | phosphorylation up-regulates → | DDAH2 PSer253 | phosphorylation down-regulates ⊣ | DDAH2 | 33850055 | SIGNOR-275646 |
| TBK1 | phosphorylation up-regulates → | OPTN PSer473 | phosphorylation up-regulates → | OPTN | 26365381 | SIGNOR-278170 |
| TBK1 | phosphorylation up-regulates → | SQSTM1 PSer403 | phosphorylation up-regulates → | SQSTM1 | 22921120 | SIGNOR-191944 |
| TBK1 | phosphorylation up-regulates → | DDAH2 PSer245 | phosphorylation down-regulates ⊣ | DDAH2 | 33850055 | SIGNOR-275648 |
| TBK1 | phosphorylation up-regulates → | STAT6 PTyr641 | phosphorylation up-regulates → | STAT6 | 22000020 | SIGNOR-176775 |
| TBK1 | phosphorylation up-regulates → | IRF3 PSer396 | phosphorylation up-regulates → | IRF3 | 18440553 | SIGNOR-178399 |
| TBK1 | phosphorylation up-regulates → | SIKE1 PSer133 | phosphorylation up-regulates → | SIKE1 | 23649622 | SIGNOR-273815 |
| TBK1 | phosphorylation up-regulates → | SIKE1 PSer188 | phosphorylation up-regulates → | SIKE1 | 23649622 | SIGNOR-273816 |
| TBK1 | phosphorylation up-regulates → | STX17 PSer202 | phosphorylation up-regulates → | STX17 | 30827897 | SIGNOR-273812 |
| TBK1 | phosphorylation up-regulates → | PBXIP1 PSer147 | phosphorylation down-regulates ⊣ | PBXIP1 | 24488098 | SIGNOR-273811 |
| TBK1 | phosphorylation up-regulates → | SIKE1 PSer190 | phosphorylation up-regulates → | SIKE1 | 23649622 | SIGNOR-273817 |
| TBK1 | phosphorylation up-regulates → | SIKE1 PSer198 | phosphorylation up-regulates → | SIKE1 | 23649622 | SIGNOR-273818 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| TBK1 | phosphorylation down-regulates quantity by destabilization | TNIP1 | SIGNOR-275734 |
| TBK1 | phosphorylation down-regulates quantity by destabilization | PBXIP1 | SIGNOR-273643 |
| TBK1 | phosphorylation → up-regulates | REL/RELA | SIGNOR-217667 |
| TBK1 | phosphorylation → up-regulates activity | IKBKB | SIGNOR-280017 |
| TBK1 | phosphorylation → up-regulates activity | CALCOCO2 | SIGNOR-280151 |
| TBK1 | phosphorylation → down-regulates quantity | SIKE1 | SIGNOR-280152 |
| TBK1 | phosphorylation down-regulates quantity by destabilization | TNIP1 | SIGNOR-280153 |
| TBK1 | phosphorylation → up-regulates activity | IRF3 | SIGNOR-120355 |
| TBK1 | phosphorylation → up-regulates | IRF5 | SIGNOR-196528 |
| TBK1 | phosphorylation → up-regulates activity | METTL3 | SIGNOR-279299 |
| TBK1 | phosphorylation → down-regulates activity | DDAH2 | SIGNOR-275647 |
| TBK1 | phosphorylation → up-regulates activity | PRPS2 | SIGNOR-277317 |
| TBK1 | phosphorylation → up-regulates activity | ELF4 | SIGNOR-279130 |
| TBK1 | phosphorylation down-regulates quantity by destabilization | NFKBIA | SIGNOR-246643 |
| TBK1 | phosphorylation → up-regulates activity | NfKb-p65/p50 | SIGNOR-260157 |
| TBK1 | phosphorylation → up-regulates activity | IRF3 | SIGNOR-178407 |
| TBK1 | phosphorylation → up-regulates | AKT | SIGNOR-172132 |
| TBK1 | phosphorylation → up-regulates activity | IRF3 | SIGNOR-178403 |
| TBK1 | phosphorylation down-regulates quantity by destabilization | MAP3K14 | SIGNOR-279767 |
| TBK1 | phosphorylation → up-regulates activity | OPTN | SIGNOR-278169 |
| TBK1 | phosphorylation → down-regulates activity | RIPK1 | SIGNOR-279388 |
| TBK1 | phosphorylation → down-regulates activity | VPS37C | SIGNOR-279768 |
| TBK1 | phosphorylation → up-regulates | STAT6 | SIGNOR-176771 |
| TBK1 | phosphorylation → up-regulates activity | IRF3 | SIGNOR-178395 |
| TBK1 | phosphorylation → up-regulates | AKT1 | SIGNOR-252608 |
| TBK1 | phosphorylation → down-regulates activity | CDH1 | SIGNOR-278996 |
| TBK1 | phosphorylation → up-regulates activity | DDX3X | SIGNOR-278997 |
| TBK1 | phosphorylation → up-regulates activity | OPTN | SIGNOR-278171 |
| TBK1 | phosphorylation → up-regulates activity | HDAC3 | SIGNOR-279662 |
| TBK1 | phosphorylation → up-regulates quantity | SIKE1 | SIGNOR-273814 |
| TBK1 | phosphorylation → up-regulates activity | IRF3 | SIGNOR-178420 |
| TBK1 | phosphorylation down-regulates quantity by destabilization | TNIP1 | SIGNOR-275733 |
| TBK1 | phosphorylation → up-regulates activity | SLC6A4 | SIGNOR-278384 |
| TBK1 | phosphorylation → up-regulates | IRF5 | SIGNOR-196532 |
| TBK1 | phosphorylation → up-regulates activity | IRF3 | SIGNOR-178391 |
| TBK1 | phosphorylation → up-regulates activity | STING1 | SIGNOR-263136 |
| TBK1 | phosphorylation → up-regulates activity | HTT | SIGNOR-270350 |
| TBK1 | phosphorylation → up-regulates activity | IRF7 | SIGNOR-278216 |
| TBK1 | phosphorylation → up-regulates activity | MTOR | SIGNOR-278237 |
| TBK1 | phosphorylation → up-regulates | REL | SIGNOR-148623 |
| TBK1 | phosphorylation → up-regulates activity | PRPS1 | SIGNOR-277316 |
| TBK1 | phosphorylation → up-regulates | RELA | SIGNOR-129951 |
| TBK1 | phosphorylation → down-regulates activity | CDC20 | SIGNOR-279766 |
| TBK1 | phosphorylation → up-regulates quantity | SIKE1 | SIGNOR-273813 |
| TBK1 | phosphorylation → down-regulates activity | DDAH2 | SIGNOR-275645 |
| TBK1 | phosphorylation → up-regulates activity | IRF3 | SIGNOR-178411 |
| TBK1 | phosphorylation → down-regulates activity | DDAH2 | SIGNOR-275646 |
| TBK1 | phosphorylation → up-regulates activity | OPTN | SIGNOR-278170 |
| TBK1 | phosphorylation → up-regulates | SQSTM1 | SIGNOR-191944 |
| TBK1 | phosphorylation → down-regulates activity | DDAH2 | SIGNOR-275648 |
| TBK1 | phosphorylation → up-regulates | STAT6 | SIGNOR-176775 |
| TBK1 | phosphorylation → up-regulates activity | IRF3 | SIGNOR-178399 |
| TBK1 | phosphorylation → up-regulates quantity | SIKE1 | SIGNOR-273815 |
| TBK1 | phosphorylation → up-regulates quantity | SIKE1 | SIGNOR-273816 |
| TBK1 | phosphorylation → up-regulates activity | STX17 | SIGNOR-273812 |
| TBK1 | phosphorylation down-regulates quantity by destabilization | PBXIP1 | SIGNOR-273811 |
| TBK1 | phosphorylation → up-regulates quantity | SIKE1 | SIGNOR-273817 |
| TBK1 | phosphorylation → up-regulates quantity | SIKE1 | SIGNOR-273818 |
| TBK1 | phosphorylation → up-regulates activity | IRF3 | SIGNOR-260154 |
| TBK1 | phosphorylation → up-regulates activity | NUMA1 | SIGNOR-278432 |