| Name | TBK1 |
| ID | Q9UHD2 |
| Role | substrate |
| Enzymatic Domains |
Protein kinase 9-310 PROSITE-ProRule
Ubiquitin-like 309-385 |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPM1A | TBK1 | Ser172 | EDDEQFVsLYGTEEY | dephosphorylation down-regulates activity | 27419230 | SIGNOR-276966 |
| DYRK2 | TBK1 | Ser527 | QDIDSRLsPGGSLAD | phosphorylation down-regulates quantity by destabilization | 26407194 | SIGNOR-276939 |
| FGR | TBK1 | Tyr354 | SSNQELIyEGRRLVL | phosphorylation down-regulates activity | 28618271 | SIGNOR-276725 |
| PPM1B | TBK1 | – | dephosphorylation down-regulates activity | 22750291 | SIGNOR-276985 | |
| HCK | TBK1 | Tyr354 | SSNQELIyEGRRLVL | phosphorylation down-regulates activity | 28618271 | SIGNOR-276726 |
| LCK | TBK1 | Tyr354 | SSNQELIyEGRRLVL | phosphorylation down-regulates activity | 28618271 | SIGNOR-276724 |
| LCK | TBK1 | Tyr394 | LNTIGLIyEKISLPK | phosphorylation down-regulates activity | 28618271 | SIGNOR-276723 |
| FGR | TBK1 | Tyr394 | LNTIGLIyEKISLPK | phosphorylation down-regulates activity | 28618271 | SIGNOR-276722 |
| HCK | TBK1 | Tyr394 | LNTIGLIyEKISLPK | phosphorylation down-regulates activity | 28618271 | SIGNOR-276727 |
| RIPK1 | TBK1 | – | phosphorylation up-regulates activity | 36198273 | SIGNOR-279278 | |
| PRKCQ | TBK1 | Ser716 | HILERFGsLTMDGGL | phosphorylation up-regulates activity | 31792381 | SIGNOR-272472 |
| PTK2B | TBK1 | Tyr591 | KFDKQKLyYHATKAM | phosphorylation up-regulates activity | 37989995 | SIGNOR-277910 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPM1A | dephosphorylation down-regulates ⊣ | TBK1 PSer172 | dephosphorylation up-regulates → | TBK1 | 27419230 | SIGNOR-276966 |
| DYRK2 | phosphorylation up-regulates → | TBK1 PSer527 | phosphorylation down-regulates ⊣ | TBK1 | 26407194 | SIGNOR-276939 |
| FGR | phosphorylation up-regulates → | TBK1 PTyr354 | phosphorylation down-regulates ⊣ | TBK1 | 28618271 | SIGNOR-276725 |
| HCK | phosphorylation up-regulates → | TBK1 PTyr354 | phosphorylation down-regulates ⊣ | TBK1 | 28618271 | SIGNOR-276726 |
| LCK | phosphorylation up-regulates → | TBK1 PTyr354 | phosphorylation down-regulates ⊣ | TBK1 | 28618271 | SIGNOR-276724 |
| LCK | phosphorylation up-regulates → | TBK1 PTyr394 | phosphorylation down-regulates ⊣ | TBK1 | 28618271 | SIGNOR-276723 |
| FGR | phosphorylation up-regulates → | TBK1 PTyr394 | phosphorylation down-regulates ⊣ | TBK1 | 28618271 | SIGNOR-276722 |
| HCK | phosphorylation up-regulates → | TBK1 PTyr394 | phosphorylation down-regulates ⊣ | TBK1 | 28618271 | SIGNOR-276727 |
| PRKCQ | phosphorylation up-regulates → | TBK1 PSer716 | phosphorylation up-regulates → | TBK1 | 31792381 | SIGNOR-272472 |
| PTK2B | phosphorylation up-regulates → | TBK1 PTyr591 | phosphorylation up-regulates → | TBK1 | 37989995 | SIGNOR-277910 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PPM1A | dephosphorylation → down-regulates activity | TBK1 | SIGNOR-276966 |
| DYRK2 | phosphorylation down-regulates quantity by destabilization | TBK1 | SIGNOR-276939 |
| FGR | phosphorylation → down-regulates activity | TBK1 | SIGNOR-276725 |
| PPM1B | dephosphorylation → down-regulates activity | TBK1 | SIGNOR-276985 |
| HCK | phosphorylation → down-regulates activity | TBK1 | SIGNOR-276726 |
| LCK | phosphorylation → down-regulates activity | TBK1 | SIGNOR-276724 |
| LCK | phosphorylation → down-regulates activity | TBK1 | SIGNOR-276723 |
| FGR | phosphorylation → down-regulates activity | TBK1 | SIGNOR-276722 |
| HCK | phosphorylation → down-regulates activity | TBK1 | SIGNOR-276727 |
| RIPK1 | phosphorylation → up-regulates activity | TBK1 | SIGNOR-279278 |
| PRKCQ | phosphorylation → up-regulates activity | TBK1 | SIGNOR-272472 |
| PTK2B | phosphorylation → up-regulates activity | TBK1 | SIGNOR-277910 |