Entity Details

Name LCK_Tyr354
ID Q9UHD2
Role residue
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
HCKTBK1Tyr354SSNQELIyEGRRLVLphosphorylation
down-regulates activity		28618271SIGNOR-276726
FGRTBK1Tyr354SSNQELIyEGRRLVLphosphorylation
down-regulates activity		28618271SIGNOR-276725
LCKTBK1Tyr354SSNQELIyEGRRLVLphosphorylation
down-regulates activity		28618271SIGNOR-276724
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
HCKphosphorylation
up-regulates
→
TBK1
PTyr354		phosphorylation
down-regulates
⊣		TBK128618271SIGNOR-276726
FGRphosphorylation
up-regulates
→
TBK1
PTyr354		phosphorylation
down-regulates
⊣		TBK128618271SIGNOR-276725
LCKphosphorylation
up-regulates
→
TBK1
PTyr354		phosphorylation
down-regulates
⊣		TBK128618271SIGNOR-276724
Regulator Mechanism/Effect Target SIGNOR-ID
HCKphosphorylation
→
down-regulates activity 		TBK1SIGNOR-276726
FGRphosphorylation
→
down-regulates activity 		TBK1SIGNOR-276725
LCKphosphorylation
→
down-regulates activity 		TBK1SIGNOR-276724