Entity Details

Name USP25
ID Q9UHP3
Role substrate
Enzymatic Domains
UBA-like 14-57
UIM 1 97-116
PROSITE-ProRule
UIM 2 123-140
PROSITE-ProRule
USP 169-657
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
VRK2USP25Thr727QKLRESEtSVTTAQAphosphorylation
down-regulates activity		25755282SIGNOR-273578
VRK2USP25Thr680QPLVGIEtLPPDLRDphosphorylation
down-regulates activity		25755282SIGNOR-273580
SYKUSP25Tyr740QAAGDPEyLEQPSRSphosphorylation
down-regulates quantity		19909739SIGNOR-278458
VRK2USP25Ser745PEYLEQPsRSDFSKHphosphorylation
down-regulates activity		25755282SIGNOR-273579
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
VRK2phosphorylation
up-regulates
→
USP25
PThr727		phosphorylation
down-regulates
⊣		USP2525755282SIGNOR-273578
VRK2phosphorylation
up-regulates
→
USP25
PThr680		phosphorylation
down-regulates
⊣		USP2525755282SIGNOR-273580
SYKphosphorylation
up-regulates
→
USP25
PTyr740		phosphorylation
down-regulates
⊣		USP2519909739SIGNOR-278458
VRK2phosphorylation
up-regulates
→
USP25
PSer745		phosphorylation
down-regulates
⊣		USP2525755282SIGNOR-273579
Regulator Mechanism/Effect Target SIGNOR-ID
VRK2phosphorylation
→
down-regulates activity 		USP25SIGNOR-273578
VRK2phosphorylation
→
down-regulates activity 		USP25SIGNOR-273580
SYKphosphorylation
→
down-regulates quantity 		USP25SIGNOR-278458
VRK2phosphorylation
→
down-regulates activity 		USP25SIGNOR-273579