| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| WNK1 | SLC12A6 | Thr991 | SAYTYERtLMMEQRS | phosphorylation down-regulates | 19665974 | SIGNOR-187564 |
| STK39 | SLC12A6 | Ser96 | IEDLSQNsITGEHSQ | phosphorylation down-regulates activity | 24043619 | SIGNOR-276597 |
| WNK3 | SLC12A6 | Thr1048 | YQEKVHMtWTKDKYM | phosphorylation down-regulates activity | 24043619 | SIGNOR-260910 |
| WNK3 | SLC12A6 | Thr991 | SAYTYERtLMMEQRS | phosphorylation down-regulates activity | 24043619 | SIGNOR-260912 |
| WNK3 | SLC12A6 | Ser96 | IEDLSQNsITGEHSQ | phosphorylation down-regulates activity | 24043619 | SIGNOR-260911 |
| WNK3 | SLC12A6 | – | phosphorylation down-regulates activity | 21613606 | SIGNOR-264629 | |
| WNK1 | SLC12A6 | Thr1048 | YQEKVHMtWTKDKYM | phosphorylation down-regulates | 19665974 | SIGNOR-187560 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| WNK1 | phosphorylation up-regulates → | SLC12A6 PThr991 | phosphorylation down-regulates ⊣ | SLC12A6 | 19665974 | SIGNOR-187564 |
| STK39 | phosphorylation up-regulates → | SLC12A6 PSer96 | phosphorylation down-regulates ⊣ | SLC12A6 | 24043619 | SIGNOR-276597 |
| WNK3 | phosphorylation up-regulates → | SLC12A6 PThr1048 | phosphorylation down-regulates ⊣ | SLC12A6 | 24043619 | SIGNOR-260910 |
| WNK3 | phosphorylation up-regulates → | SLC12A6 PThr991 | phosphorylation down-regulates ⊣ | SLC12A6 | 24043619 | SIGNOR-260912 |
| WNK3 | phosphorylation up-regulates → | SLC12A6 PSer96 | phosphorylation down-regulates ⊣ | SLC12A6 | 24043619 | SIGNOR-260911 |
| WNK1 | phosphorylation up-regulates → | SLC12A6 PThr1048 | phosphorylation down-regulates ⊣ | SLC12A6 | 19665974 | SIGNOR-187560 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| WNK1 | phosphorylation down-regulates | SLC12A6 | SIGNOR-187564 |
| STK39 | phosphorylation → down-regulates activity | SLC12A6 | SIGNOR-276597 |
| WNK3 | phosphorylation → down-regulates activity | SLC12A6 | SIGNOR-260910 |
| WNK3 | phosphorylation → down-regulates activity | SLC12A6 | SIGNOR-260912 |
| WNK3 | phosphorylation → down-regulates activity | SLC12A6 | SIGNOR-260911 |
| WNK3 | phosphorylation → down-regulates activity | SLC12A6 | SIGNOR-264629 |
| WNK1 | phosphorylation down-regulates | SLC12A6 | SIGNOR-187560 |
