| Name | HSPB8 |
| ID | Q9UJY1 |
| Role | substrate |
| Enzymatic Domains |
sHSP 74-185 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PKA | HSPB8 | Ser24 | RRDPFRDsPLSSRLL | phosphorylation down-regulates quantity by destabilization | 18298377 | SIGNOR-276152 |
| PRKCA | HSPB8 | Ser14 | PFSCHYPsRLRRDPF | phosphorylation up-regulates | 22721717 | SIGNOR-197940 |
| PRKCA | HSPB8 | Thr63 | LSSAWPGtLRSGMVP | phosphorylation up-regulates activity | 11342557 | SIGNOR-107688 |
| MAPK3 | HSPB8 | Thr87 | GVPAEGRtPPPFPGE | phosphorylation up-regulates | 22721717 | SIGNOR-197936 |
| PRKCA | HSPB8 | Thr63 | LSSAWPGtLRSGMVP | phosphorylation up-regulates | 22721717 | SIGNOR-197949 |
| PKA | HSPB8 | Ser57 | DWALPRLsSAWPGTL | phosphorylation down-regulates quantity by destabilization | 18298377 | SIGNOR-276151 |
| MAPK3 | HSPB8 | Ser27 | PFRDSPLsSRLLDDG | phosphorylation up-regulates | 22721717 | SIGNOR-197932 |
| PRKCA | HSPB8 | Ser14 | PFSCHYPsRLRRDPF | phosphorylation up-regulates activity | 11342557 | SIGNOR-107684 |
| MAPK3 | HSPB8 | Thr87 | GVPAEGRtPPPFPGE | phosphorylation up-regulates activity | 11342557 | SIGNOR-107680 |
| MAPK3 | HSPB8 | Ser27 | PFRDSPLsSRLLDDG | phosphorylation up-regulates activity | 11342557 | SIGNOR-107676 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PKA | phosphorylation up-regulates → | HSPB8 PSer24 | phosphorylation down-regulates ⊣ | HSPB8 | 18298377 | SIGNOR-276152 |
| PRKCA | phosphorylation up-regulates → | HSPB8 PSer14 | phosphorylation up-regulates → | HSPB8 | 22721717 | SIGNOR-197940 |
| PRKCA | phosphorylation up-regulates → | HSPB8 PThr63 | phosphorylation up-regulates → | HSPB8 | 11342557 | SIGNOR-107688 |
| MAPK3 | phosphorylation up-regulates → | HSPB8 PThr87 | phosphorylation up-regulates → | HSPB8 | 22721717 | SIGNOR-197936 |
| PRKCA | phosphorylation up-regulates → | HSPB8 PThr63 | phosphorylation up-regulates → | HSPB8 | 22721717 | SIGNOR-197949 |
| PKA | phosphorylation up-regulates → | HSPB8 PSer57 | phosphorylation down-regulates ⊣ | HSPB8 | 18298377 | SIGNOR-276151 |
| MAPK3 | phosphorylation up-regulates → | HSPB8 PSer27 | phosphorylation up-regulates → | HSPB8 | 22721717 | SIGNOR-197932 |
| PRKCA | phosphorylation up-regulates → | HSPB8 PSer14 | phosphorylation up-regulates → | HSPB8 | 11342557 | SIGNOR-107684 |
| MAPK3 | phosphorylation up-regulates → | HSPB8 PThr87 | phosphorylation up-regulates → | HSPB8 | 11342557 | SIGNOR-107680 |
| MAPK3 | phosphorylation up-regulates → | HSPB8 PSer27 | phosphorylation up-regulates → | HSPB8 | 11342557 | SIGNOR-107676 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PKA | phosphorylation down-regulates quantity by destabilization | HSPB8 | SIGNOR-276152 |
| PRKCA | phosphorylation → up-regulates | HSPB8 | SIGNOR-197940 |
| PRKCA | phosphorylation → up-regulates activity | HSPB8 | SIGNOR-107688 |
| MAPK3 | phosphorylation → up-regulates | HSPB8 | SIGNOR-197936 |
| PRKCA | phosphorylation → up-regulates | HSPB8 | SIGNOR-197949 |
| PKA | phosphorylation down-regulates quantity by destabilization | HSPB8 | SIGNOR-276151 |
| MAPK3 | phosphorylation → up-regulates | HSPB8 | SIGNOR-197932 |
| PRKCA | phosphorylation → up-regulates activity | HSPB8 | SIGNOR-107684 |
| MAPK3 | phosphorylation → up-regulates activity | HSPB8 | SIGNOR-107680 |
| MAPK3 | phosphorylation → up-regulates activity | HSPB8 | SIGNOR-107676 |