| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| EGFR | KCND3 | Tyr136 | GDCCYEEyKDRKREN | phosphorylation up-regulates activity | 22198508 | SIGNOR-276397 |
| LYN | KCND3 | Tyr108 | GKLHYPRyECISAYD | phosphorylation up-regulates activity | 22198508 | SIGNOR-276395 |
| SRC_kinase_family | KCND3 | Tyr108 | GKLHYPRyECISAYD | phosphorylation up-regulates activity | 22198508 | SIGNOR-275566 |
| SRC | KCND3 | Tyr108 | GKLHYPRyECISAYD | phosphorylation up-regulates activity | 22198508 | SIGNOR-276393 |
| FGR | KCND3 | Tyr108 | GKLHYPRyECISAYD | phosphorylation up-regulates activity | 22198508 | SIGNOR-276394 |
| FYN | KCND3 | Tyr108 | GKLHYPRyECISAYD | phosphorylation up-regulates activity | 22198508 | SIGNOR-276396 |
| EGFR | KCND3 | Tyr136 | GDCCYEEyKDRKREN | phosphorylation up-regulates activity | 22198508 | SIGNOR-275549 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| EGFR | phosphorylation up-regulates → | KCND3 PTyr136 | phosphorylation up-regulates → | KCND3 | 22198508 | SIGNOR-276397 |
| LYN | phosphorylation up-regulates → | KCND3 PTyr108 | phosphorylation up-regulates → | KCND3 | 22198508 | SIGNOR-276395 |
| SRC_kinase_family | phosphorylation up-regulates → | KCND3 PTyr108 | phosphorylation up-regulates → | KCND3 | 22198508 | SIGNOR-275566 |
| SRC | phosphorylation up-regulates → | KCND3 PTyr108 | phosphorylation up-regulates → | KCND3 | 22198508 | SIGNOR-276393 |
| FGR | phosphorylation up-regulates → | KCND3 PTyr108 | phosphorylation up-regulates → | KCND3 | 22198508 | SIGNOR-276394 |
| FYN | phosphorylation up-regulates → | KCND3 PTyr108 | phosphorylation up-regulates → | KCND3 | 22198508 | SIGNOR-276396 |
| EGFR | phosphorylation up-regulates → | KCND3 PTyr136 | phosphorylation up-regulates → | KCND3 | 22198508 | SIGNOR-275549 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| EGFR | phosphorylation → up-regulates activity | KCND3 | SIGNOR-276397 |
| LYN | phosphorylation → up-regulates activity | KCND3 | SIGNOR-276395 |
| SRC_kinase_family | phosphorylation → up-regulates activity | KCND3 | SIGNOR-275566 |
| SRC | phosphorylation → up-regulates activity | KCND3 | SIGNOR-276393 |
| FGR | phosphorylation → up-regulates activity | KCND3 | SIGNOR-276394 |
| FYN | phosphorylation → up-regulates activity | KCND3 | SIGNOR-276396 |
| EGFR | phosphorylation → up-regulates activity | KCND3 | SIGNOR-275549 |
