Entity Details

Name RPS6KA6
ID Q9UK32
Role kinase
Enzymatic Domains
Protein kinase 1 73-330
PROSITE-ProRule
AGC-kinase C-terminal 331-400
PROSITE-ProRule
Protein kinase 2 426-683
PROSITE-ProRule
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
RPS6KA6GSK3BSer9SGRPRTTsFAESCKPphosphorylation
down-regulates activity		32396532SIGNOR-275801
RPS6KA6EP300Ser89SELLRSGsSPNLNMGphosphorylation
down-regulates activity		34261798SIGNOR-275796
RPS6KA6RPS6KA6Ser232DQEKKAYsFCGTVEYphosphorylation
up-regulates activity		15632195SIGNOR-275797
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
RPS6KA6phosphorylation
up-regulates
→
GSK3B
PSer9		phosphorylation
down-regulates
⊣		GSK3B32396532SIGNOR-275801
RPS6KA6phosphorylation
up-regulates
→
EP300
PSer89		phosphorylation
down-regulates
⊣		EP30034261798SIGNOR-275796
RPS6KA6phosphorylation
up-regulates
→
RPS6KA6
PSer232		phosphorylation
up-regulates
→		RPS6KA615632195SIGNOR-275797
Regulator Mechanism/Effect Target SIGNOR-ID
RPS6KA6phosphorylation
→
down-regulates activity 		GSK3BSIGNOR-275801
RPS6KA6phosphorylation
→
down-regulates activity 		EP300SIGNOR-275796
RPS6KA6phosphorylation
→
up-regulates activity 		RPS6KA6SIGNOR-275797