Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
TNIK	GSN	–		phosphorylation up-regulates activity	18701680	SIGNOR-280154
TNIK	NF2	Ser13	ASRMSFSsLKRKQPK	phosphorylation up-regulates activity	33495197	SIGNOR-278388
TNIK	NF2	Ser315	MRRRKADsLEVQQMK	phosphorylation up-regulates activity	33495197	SIGNOR-278387
TNIK	NF2	Thr272	SYSDKEFtIKPLDKK	phosphorylation up-regulates activity	33495197	SIGNOR-278386
TNIK	NF2	Thr576	GGSSKHNtIKKLTLQ	phosphorylation up-regulates activity	33495197	SIGNOR-278385
TNIK	SMAD1	Thr322	SNVNRNStIENTRRH	phosphorylation down-regulates activity	21690388	SIGNOR-276334
TNIK	TCF7L2	Ser177	QALKDARsPSPAHIV	phosphorylation up-regulates	20530691	SIGNOR-165946

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
TNIK	phosphorylation up-regulates →	NF2 PSer13	phosphorylation up-regulates →	NF2	33495197	SIGNOR-278388
TNIK	phosphorylation up-regulates →	NF2 PSer315	phosphorylation up-regulates →	NF2	33495197	SIGNOR-278387
TNIK	phosphorylation up-regulates →	NF2 PThr272	phosphorylation up-regulates →	NF2	33495197	SIGNOR-278386
TNIK	phosphorylation up-regulates →	NF2 PThr576	phosphorylation up-regulates →	NF2	33495197	SIGNOR-278385
TNIK	phosphorylation up-regulates →	SMAD1 PThr322	phosphorylation down-regulates ⊣	SMAD1	21690388	SIGNOR-276334
TNIK	phosphorylation up-regulates →	TCF7L2 PSer177	phosphorylation up-regulates →	TCF7L2	20530691	SIGNOR-165946

Regulator	Mechanism/Effect	Target	SIGNOR-ID
TNIK	phosphorylation → up-regulates activity	GSN	SIGNOR-280154
TNIK	phosphorylation → up-regulates activity	NF2	SIGNOR-278388
TNIK	phosphorylation → up-regulates activity	NF2	SIGNOR-278387
TNIK	phosphorylation → up-regulates activity	NF2	SIGNOR-278386
TNIK	phosphorylation → up-regulates activity	NF2	SIGNOR-278385
TNIK	phosphorylation → down-regulates activity	SMAD1	SIGNOR-276334
TNIK	phosphorylation → up-regulates	TCF7L2	SIGNOR-165946