Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
TLK1	H3C1	Ser11	TKQTARKsTGGKAPR	phosphorylation up-regulates activity	11314006	SIGNOR-107037
TLK1	MAPKAPK5	Ser160	NLLFKDNsLDAPVKL	phosphorylation up-regulates activity	35064619	SIGNOR-276745
TLK1	MAPKAPK5	Ser354	VSLKPLHsVNNPILR	phosphorylation up-regulates activity	35064619	SIGNOR-276746
TLK1	MAPKAPK5	Ser386	HENGAEDsNVALEKL	phosphorylation up-regulates activity	35064619	SIGNOR-276747
TLK1	NEK1	Thr141	IFLTKDGtVQLGDFG	phosphorylation up-regulates activity	28426283	SIGNOR-275840
TLK1	NEK1	Thr141	IFLTKDGtVQLGDFG	phosphorylation up-regulates activity	31914854	SIGNOR-279301
TLK1	RAD9A	Ser328	VLPSISLsPGPQPPK	phosphorylation unknown	24376897	SIGNOR-203499
TLK1	RAD9A	Thr355	EPSTVPGtPPPKKFR	phosphorylation unknown	24376897	SIGNOR-203503
TLK1	RAD9A	Ser328	VLPSISLsPGPQPPK	phosphorylation up-regulates	18940270	SIGNOR-181748
TLK1	Histone H3	–		phosphorylation up-regulates activity	11314006	SIGNOR-265370

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
TLK1	phosphorylation up-regulates →	H3C1 PSer11	phosphorylation up-regulates →	H3C1	11314006	SIGNOR-107037
TLK1	phosphorylation up-regulates →	MAPKAPK5 PSer160	phosphorylation up-regulates →	MAPKAPK5	35064619	SIGNOR-276745
TLK1	phosphorylation up-regulates →	MAPKAPK5 PSer354	phosphorylation up-regulates →	MAPKAPK5	35064619	SIGNOR-276746
TLK1	phosphorylation up-regulates →	MAPKAPK5 PSer386	phosphorylation up-regulates →	MAPKAPK5	35064619	SIGNOR-276747
TLK1	phosphorylation up-regulates →	NEK1 PThr141	phosphorylation up-regulates →	NEK1	28426283	SIGNOR-275840
TLK1	phosphorylation up-regulates →	NEK1 PThr141	phosphorylation up-regulates →	NEK1	31914854	SIGNOR-279301
TLK1	phosphorylation up-regulates →	RAD9A PSer328	phosphorylation down-regulates ⊣	RAD9A	24376897	SIGNOR-203499
TLK1	phosphorylation up-regulates →	RAD9A PThr355	phosphorylation down-regulates ⊣	RAD9A	24376897	SIGNOR-203503
TLK1	phosphorylation up-regulates →	RAD9A PSer328	phosphorylation up-regulates →	RAD9A	18940270	SIGNOR-181748

Regulator	Mechanism/Effect	Target	SIGNOR-ID
TLK1	phosphorylation → up-regulates activity	H3C1	SIGNOR-107037
TLK1	phosphorylation → up-regulates activity	MAPKAPK5	SIGNOR-276745
TLK1	phosphorylation → up-regulates activity	MAPKAPK5	SIGNOR-276746
TLK1	phosphorylation → up-regulates activity	MAPKAPK5	SIGNOR-276747
TLK1	phosphorylation → up-regulates activity	NEK1	SIGNOR-275840
TLK1	phosphorylation → up-regulates activity	NEK1	SIGNOR-279301
TLK1	phosphorylation → unknown	RAD9A	SIGNOR-203499
TLK1	phosphorylation → unknown	RAD9A	SIGNOR-203503
TLK1	phosphorylation → up-regulates	RAD9A	SIGNOR-181748
TLK1	phosphorylation → up-regulates activity	Histone H3	SIGNOR-265370