Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
PTPN1	AGO2	Tyr393	ASFNTDPyVREFGIM	dephosphorylation down-regulates activity	25175024	SIGNOR-277120
AKT3	AGO2	Ser387 View in OncoXplorer	SKLMRSAsFNTDPYV	phosphorylation up-regulates	23603119	SIGNOR-201918
CSNK1A1	AGO2	Ser834 View in OncoXplorer	GSHTSGQsNGRDHQA	phosphorylation down-regulates activity	28114302	SIGNOR-276509
CSNK1A1	AGO2	Ser828	EHDSAEGsHTSGQSN	phosphorylation down-regulates activity	28114302	SIGNOR-276512
PPP6C	AGO2	Ser824 View in OncoXplorer	LVDKEHDsAEGSHTS	dephosphorylation up-regulates activity	28114302	SIGNOR-276516
AKT3	AGO2	Ser387 View in OncoXplorer	SKLMRSAsFNTDPYV	phosphorylation up-regulates	18476811	SIGNOR-178416
EGFR	AGO2	Tyr393	ASFNTDPyVREFGIM	phosphorylation up-regulates activity	25137592	SIGNOR-278931
PPP6C	AGO2	Ser834 View in OncoXplorer	GSHTSGQsNGRDHQA	dephosphorylation up-regulates activity	28114302	SIGNOR-276514
PPP6C	AGO2	Ser831 View in OncoXplorer	SAEGSHTsGQSNGRD	dephosphorylation up-regulates activity	28114302	SIGNOR-276513
CSNK1A1	AGO2	–		phosphorylation down-regulates activity	28114302	SIGNOR-279699
CSNK1A1	AGO2	Ser824 View in OncoXplorer	LVDKEHDsAEGSHTS	phosphorylation down-regulates activity	28114302	SIGNOR-276511
MAPKAPK2	AGO2	Ser387 View in OncoXplorer	SKLMRSAsFNTDPYV	phosphorylation up-regulates	20626350	SIGNOR-166615
PPP6C	AGO2	Thr830	DSAEGSHtSGQSNGR	dephosphorylation up-regulates activity	28114302	SIGNOR-276515
CSNK1A1	AGO2	Ser831 View in OncoXplorer	SAEGSHTsGQSNGRD	phosphorylation down-regulates activity	28114302	SIGNOR-276508
PPP6C	AGO2	Ser828	EHDSAEGsHTSGQSN	dephosphorylation up-regulates activity	28114302	SIGNOR-276517
CSNK1A1	AGO2	Thr830	DSAEGSHtSGQSNGR	phosphorylation down-regulates activity	28114302	SIGNOR-276510

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
PTPN1	dephosphorylation down-regulates ⊣	AGO2 PTyr393	dephosphorylation up-regulates →	AGO2	25175024	SIGNOR-277120
AKT3	phosphorylation up-regulates →	AGO2 PSer387	phosphorylation up-regulates →	AGO2	23603119	SIGNOR-201918
CSNK1A1	phosphorylation up-regulates →	AGO2 PSer834	phosphorylation down-regulates ⊣	AGO2	28114302	SIGNOR-276509
CSNK1A1	phosphorylation up-regulates →	AGO2 PSer828	phosphorylation down-regulates ⊣	AGO2	28114302	SIGNOR-276512
PPP6C	dephosphorylation down-regulates ⊣	AGO2 PSer824	dephosphorylation down-regulates ⊣	AGO2	28114302	SIGNOR-276516
AKT3	phosphorylation up-regulates →	AGO2 PSer387	phosphorylation up-regulates →	AGO2	18476811	SIGNOR-178416
EGFR	phosphorylation up-regulates →	AGO2 PTyr393	phosphorylation up-regulates →	AGO2	25137592	SIGNOR-278931
PPP6C	dephosphorylation down-regulates ⊣	AGO2 PSer834	dephosphorylation down-regulates ⊣	AGO2	28114302	SIGNOR-276514
PPP6C	dephosphorylation down-regulates ⊣	AGO2 PSer831	dephosphorylation down-regulates ⊣	AGO2	28114302	SIGNOR-276513
CSNK1A1	phosphorylation up-regulates →	AGO2 PSer824	phosphorylation down-regulates ⊣	AGO2	28114302	SIGNOR-276511
MAPKAPK2	phosphorylation up-regulates →	AGO2 PSer387	phosphorylation up-regulates →	AGO2	20626350	SIGNOR-166615
PPP6C	dephosphorylation down-regulates ⊣	AGO2 PThr830	dephosphorylation down-regulates ⊣	AGO2	28114302	SIGNOR-276515
CSNK1A1	phosphorylation up-regulates →	AGO2 PSer831	phosphorylation down-regulates ⊣	AGO2	28114302	SIGNOR-276508
PPP6C	dephosphorylation down-regulates ⊣	AGO2 PSer828	dephosphorylation down-regulates ⊣	AGO2	28114302	SIGNOR-276517
CSNK1A1	phosphorylation up-regulates →	AGO2 PThr830	phosphorylation down-regulates ⊣	AGO2	28114302	SIGNOR-276510

Regulator	Mechanism/Effect	Target	SIGNOR-ID
PTPN1	dephosphorylation → down-regulates activity	AGO2	SIGNOR-277120
AKT3	phosphorylation → up-regulates	AGO2	SIGNOR-201918
CSNK1A1	phosphorylation → down-regulates activity	AGO2	SIGNOR-276509
CSNK1A1	phosphorylation → down-regulates activity	AGO2	SIGNOR-276512
PPP6C	dephosphorylation → up-regulates activity	AGO2	SIGNOR-276516
AKT3	phosphorylation → up-regulates	AGO2	SIGNOR-178416
EGFR	phosphorylation → up-regulates activity	AGO2	SIGNOR-278931
PPP6C	dephosphorylation → up-regulates activity	AGO2	SIGNOR-276514
PPP6C	dephosphorylation → up-regulates activity	AGO2	SIGNOR-276513
CSNK1A1	phosphorylation → down-regulates activity	AGO2	SIGNOR-279699
CSNK1A1	phosphorylation → down-regulates activity	AGO2	SIGNOR-276511
MAPKAPK2	phosphorylation → up-regulates	AGO2	SIGNOR-166615
PPP6C	dephosphorylation → up-regulates activity	AGO2	SIGNOR-276515
CSNK1A1	phosphorylation → down-regulates activity	AGO2	SIGNOR-276508
PPP6C	dephosphorylation → up-regulates activity	AGO2	SIGNOR-276517
CSNK1A1	phosphorylation → down-regulates activity	AGO2	SIGNOR-276510